Allo-reactive tissue-resident T cells causing damage: An inside job

Tissue-resident memory T cells (T(RM) cells) reside in the epithelium and contribute to the first line defense against invading pathogens. Snyder et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20212059) now report that clonally expanded, recipient T cells persist as T(RM) cells in human lung...

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Detalles Bibliográficos
Autores principales: van Lier, René A.W., Hombrink, Pleun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924933/
https://www.ncbi.nlm.nih.gov/pubmed/35285872
http://dx.doi.org/10.1084/jem.20220121
Descripción
Sumario:Tissue-resident memory T cells (T(RM) cells) reside in the epithelium and contribute to the first line defense against invading pathogens. Snyder et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20212059) now report that clonally expanded, recipient T cells persist as T(RM) cells in human lung allografts despite intensive immunosuppression. Their persistence may contribute to chronic allograft dysfunction.

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