Allo-reactive tissue-resident T cells causing damage: An inside job

Tissue-resident memory T cells (T(RM) cells) reside in the epithelium and contribute to the first line defense against invading pathogens. Snyder et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20212059) now report that clonally expanded, recipient T cells persist as T(RM) cells in human lung...

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Detalles Bibliográficos
Autores principales: van Lier, René A.W., Hombrink, Pleun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924933/
https://www.ncbi.nlm.nih.gov/pubmed/35285872
http://dx.doi.org/10.1084/jem.20220121
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author van Lier, René A.W.
Hombrink, Pleun
author_facet van Lier, René A.W.
Hombrink, Pleun
author_sort van Lier, René A.W.
collection PubMed
description Tissue-resident memory T cells (T(RM) cells) reside in the epithelium and contribute to the first line defense against invading pathogens. Snyder et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20212059) now report that clonally expanded, recipient T cells persist as T(RM) cells in human lung allografts despite intensive immunosuppression. Their persistence may contribute to chronic allograft dysfunction.
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spelling pubmed-89249332022-10-04 Allo-reactive tissue-resident T cells causing damage: An inside job van Lier, René A.W. Hombrink, Pleun J Exp Med Insights Tissue-resident memory T cells (T(RM) cells) reside in the epithelium and contribute to the first line defense against invading pathogens. Snyder et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20212059) now report that clonally expanded, recipient T cells persist as T(RM) cells in human lung allografts despite intensive immunosuppression. Their persistence may contribute to chronic allograft dysfunction. Rockefeller University Press 2022-03-14 /pmc/articles/PMC8924933/ /pubmed/35285872 http://dx.doi.org/10.1084/jem.20220121 Text en © 2022 van Lier and Hombrink https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Insights
van Lier, René A.W.
Hombrink, Pleun
Allo-reactive tissue-resident T cells causing damage: An inside job
title Allo-reactive tissue-resident T cells causing damage: An inside job
title_full Allo-reactive tissue-resident T cells causing damage: An inside job
title_fullStr Allo-reactive tissue-resident T cells causing damage: An inside job
title_full_unstemmed Allo-reactive tissue-resident T cells causing damage: An inside job
title_short Allo-reactive tissue-resident T cells causing damage: An inside job
title_sort allo-reactive tissue-resident t cells causing damage: an inside job
topic Insights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924933/
https://www.ncbi.nlm.nih.gov/pubmed/35285872
http://dx.doi.org/10.1084/jem.20220121
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