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Time point of nocturnal trough systolic blood pressure as an independent predictor of cardiovascular events
Nocturnal trough systolic blood pressure (NTSBP) and Time Point of Nocturnal Trough Systolic Blood Pressure (T‐NTSBP) were important parameters of nocturnal blood pressure, the predictive values of which are unclear for stroke outcome. This study aimed to examine the relationship between NTSBP/T‐NTS...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924997/ https://www.ncbi.nlm.nih.gov/pubmed/35118806 http://dx.doi.org/10.1111/jch.14404 |
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author | Zhu, Jing Hao, Xiwa Tang, Hefei Xu, Jie Wang, Anxin Zhang, Xiaoli Wang, Yongjun |
author_facet | Zhu, Jing Hao, Xiwa Tang, Hefei Xu, Jie Wang, Anxin Zhang, Xiaoli Wang, Yongjun |
author_sort | Zhu, Jing |
collection | PubMed |
description | Nocturnal trough systolic blood pressure (NTSBP) and Time Point of Nocturnal Trough Systolic Blood Pressure (T‐NTSBP) were important parameters of nocturnal blood pressure, the predictive values of which are unclear for stroke outcome. This study aimed to examine the relationship between NTSBP/T‐NTSBP and stroke outcome. The authors used data from a nationwide ambulatory blood pressure monitoring cohort study conducted in China, which recruited 2348 ischemic stroke and transient ischemic attack (TIA) patients. NTSBP was defined as the lowest SBP during nighttime (22:00–6:00), and T‐NTSBP was defined as the corresponding time point of NTSBP. The associations between NTSBP/T‐NTSBP and stroke outcome (stroke recurrence and combined vascular event [CVE]) at 90 days or 1 year were analyzed using cox regression models. According to NTSBP classified by quartile, hazard ratio (HR) with 95% confidence interval (CI) for NTSBP quartile 4 (>129 mm Hg) was 2.727 (1.148–6.478) for CVE at 90‐day, compared with quartile 1 (≤102 mm Hg). However, an attenuated association between NTSBP and CVE was observed at 1 year. In addition, we observed the group of T‐NTSBP at 4:00–6:00 had a lowest CVE incidence at 90 days among four groups (22:00–23:59, 00:00–1:59 2:00–3:59, 4:00–6:00). After multivariable adjustment, T‐NTSBP was significantly associated with CVE incidence at 90 days (T‐NTSBP at the 4:00–6:00 versus the 22:00–23:59 group: HR, 0.433; 95%CI, 0.190–0.986), independent of NTSBP and average nocturnal SBP. Both of NTSBP and T‐NTSBP were important predictors for short‐term cardiovascular risk in ischemic stroke and TIA patients. |
format | Online Article Text |
id | pubmed-8924997 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89249972022-03-21 Time point of nocturnal trough systolic blood pressure as an independent predictor of cardiovascular events Zhu, Jing Hao, Xiwa Tang, Hefei Xu, Jie Wang, Anxin Zhang, Xiaoli Wang, Yongjun J Clin Hypertens (Greenwich) Nocturnal Blood Pressure Nocturnal trough systolic blood pressure (NTSBP) and Time Point of Nocturnal Trough Systolic Blood Pressure (T‐NTSBP) were important parameters of nocturnal blood pressure, the predictive values of which are unclear for stroke outcome. This study aimed to examine the relationship between NTSBP/T‐NTSBP and stroke outcome. The authors used data from a nationwide ambulatory blood pressure monitoring cohort study conducted in China, which recruited 2348 ischemic stroke and transient ischemic attack (TIA) patients. NTSBP was defined as the lowest SBP during nighttime (22:00–6:00), and T‐NTSBP was defined as the corresponding time point of NTSBP. The associations between NTSBP/T‐NTSBP and stroke outcome (stroke recurrence and combined vascular event [CVE]) at 90 days or 1 year were analyzed using cox regression models. According to NTSBP classified by quartile, hazard ratio (HR) with 95% confidence interval (CI) for NTSBP quartile 4 (>129 mm Hg) was 2.727 (1.148–6.478) for CVE at 90‐day, compared with quartile 1 (≤102 mm Hg). However, an attenuated association between NTSBP and CVE was observed at 1 year. In addition, we observed the group of T‐NTSBP at 4:00–6:00 had a lowest CVE incidence at 90 days among four groups (22:00–23:59, 00:00–1:59 2:00–3:59, 4:00–6:00). After multivariable adjustment, T‐NTSBP was significantly associated with CVE incidence at 90 days (T‐NTSBP at the 4:00–6:00 versus the 22:00–23:59 group: HR, 0.433; 95%CI, 0.190–0.986), independent of NTSBP and average nocturnal SBP. Both of NTSBP and T‐NTSBP were important predictors for short‐term cardiovascular risk in ischemic stroke and TIA patients. John Wiley and Sons Inc. 2022-02-03 /pmc/articles/PMC8924997/ /pubmed/35118806 http://dx.doi.org/10.1111/jch.14404 Text en © 2021 The Authors. The Journal of Clinical Hypertension published by Wiley Periodicals LLC https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Nocturnal Blood Pressure Zhu, Jing Hao, Xiwa Tang, Hefei Xu, Jie Wang, Anxin Zhang, Xiaoli Wang, Yongjun Time point of nocturnal trough systolic blood pressure as an independent predictor of cardiovascular events |
title | Time point of nocturnal trough systolic blood pressure as an independent predictor of cardiovascular events |
title_full | Time point of nocturnal trough systolic blood pressure as an independent predictor of cardiovascular events |
title_fullStr | Time point of nocturnal trough systolic blood pressure as an independent predictor of cardiovascular events |
title_full_unstemmed | Time point of nocturnal trough systolic blood pressure as an independent predictor of cardiovascular events |
title_short | Time point of nocturnal trough systolic blood pressure as an independent predictor of cardiovascular events |
title_sort | time point of nocturnal trough systolic blood pressure as an independent predictor of cardiovascular events |
topic | Nocturnal Blood Pressure |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924997/ https://www.ncbi.nlm.nih.gov/pubmed/35118806 http://dx.doi.org/10.1111/jch.14404 |
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