Integration of genetic colocalizations with physiological and pharmacological perturbations identifies cardiometabolic disease genes

BACKGROUND: Identification of causal genes for polygenic human diseases has been extremely challenging, and our understanding of how physiological and pharmacological stimuli modulate genetic risk at disease-associated loci is limited. Specifically, insulin resistance (IR), a common feature of cardi...

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Detalles Bibliográficos
Autores principales: Gloudemans, Michael J., Balliu, Brunilda, Nachun, Daniel, Schnurr, Theresia M., Durrant, Matthew G., Ingelsson, Erik, Wabitsch, Martin, Quertermous, Thomas, Montgomery, Stephen B., Knowles, Joshua W., Carcamo-Orive, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8925074/
https://www.ncbi.nlm.nih.gov/pubmed/35292083
http://dx.doi.org/10.1186/s13073-022-01036-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8925074/
https://www.ncbi.nlm.nih.gov/pubmed/35292083
http://dx.doi.org/10.1186/s13073-022-01036-8

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