Cargando…

Biodistribution and environmental safety of a live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate

New platforms are needed for the design of novel prophylactic vaccines and advanced immune therapies. Live-attenuated yellow fever vaccine YF17D serves as a vector for several licensed vaccines and platform for novel candidates. On the basis of YF17D, we developed an exceptionally potent COVID-19 va...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Li-Hsin, Liesenborghs, Laurens, Wang, Lanjiao, Lox, Marleen, Yakass, Michael Bright, Jansen, Sander, Rosales Rosas, Ana Lucia, Zhang, Xin, Thibaut, Hendrik Jan, Teuwen, Dirk, Neyts, Johan, Delang, Leen, Dallmeier, Kai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8925082/ https://www.ncbi.nlm.nih.gov/pubmed/35313504 http://dx.doi.org/10.1016/j.omtm.2022.03.010

Ejemplares similares

Live-attenuated YF17D-vectored COVID-19 vaccine protects from lethal yellow fever virus infection in mouse and hamster models
por: Ma, Ji, et al.
Publicado: (2022)

YF17D-vectored Ebola vaccine candidate protects mice against lethal surrogate Ebola and yellow fever virus challenge
por: Lemmens, Viktor, et al.
Publicado: (2023)

Ex vivo gut cultures of Aedes aegypti are efficiently infected by mosquito-borne alpha- and flaviviruses
por: Rosales Rosas, Ana Lucia, et al.
Publicado: (2023)

Understanding the Mechanisms Underlying Host Restriction of Insect-Specific Viruses
por: Elrefaey, Ahmed ME, et al.
Publicado: (2020)

In Vitro and In Vivo Model to Study Bacterial Adhesion to the Vessel Wall Under Flow Conditions
por: Claes, Jorien, et al.
Publicado: (2015)

Establishment of Culex modestus in Belgium and a Glance into the Virome of Belgian Mosquito Species
por: Wang, Lanjiao, et al.
Publicado: (2021)

Favipiravir Does Not Inhibit Chikungunya Virus Replication in Mosquito Cells and Aedes aegypti Mosquitoes
por: Jacobs, Sofie, et al.
Publicado: (2021)

Medical treatment options for COVID-19
por: Delang, Leen, et al.
Publicado: (2020)

Belgian Culex pipiens pipiens are competent vectors for West Nile virus while Culex modestus are competent vectors for Usutu virus
por: Soto, Alina, et al.
Publicado: (2023)

Antiviral Therapy for Hepatitis C Virus: Beyond the Standard of Care
por: Delang, Leen, et al.
Publicado: (2010)

The role of phosphatidylinositol 4-kinases and phosphatidylinositol 4-phosphate during viral replication
por: Delang, Leen, et al.
Publicado: (2012)

Towards antivirals against chikungunya virus
por: Abdelnabi, Rana, et al.
Publicado: (2015)

Antiviral Strategies Against Chikungunya Virus
por: Abdelnabi, Rana, et al.
Publicado: (2015)

Bidirectional Interactions between Arboviruses and the Bacterial and Viral Microbiota in Aedes aegypti and Culex quinquefasciatus
por: Shi, Chenyan, et al.
Publicado: (2022)

Repurposing Drugs for Mayaro Virus: Identification of EIDD-1931, Favipiravir and Suramin as Mayaro Virus Inhibitors
por: Langendries, Lana, et al.
Publicado: (2021)

Viral engagement with host receptors blocked by a novel class of tryptophan dendrimers that targets the 5-fold-axis of the enterovirus-A71 capsid
por: Sun, Liang, et al.
Publicado: (2019)

A novel therapeutic HBV vaccine candidate induces strong polyfunctional cytotoxic T cell responses in mice
por: Boudewijns, Robbert, et al.
Publicado: (2021)

A Viral Polymerase Inhibitor Reduces Zika Virus Replication in the Reproductive Organs of Male Mice
por: Jacobs, Sofie, et al.
Publicado: (2019)

Neutrophils Protect Against Staphylococcus aureus Endocarditis Progression Independent of Extracellular Trap Release
por: Meyers, Severien, et al.
Publicado: (2022)

SARS-CoV-2 infection causes prolonged cardiomyocyte swelling and inhibition of HIF1α translocation in an animal model COVID-19
por: Daems, Margo, et al.
Publicado: (2022)

COVID-19: should we continue to cryopreserve sperm during the pandemic?
por: Yakass, Michael Bright, et al.
Publicado: (2020)

Comparative analysis of the molecular mechanism of resistance to vapendavir across a panel of picornavirus species
por: Lanko, Kristina, et al.
Publicado: (2021)

Comparing infectivity and virulence of emerging SARS-CoV-2 variants in Syrian hamsters
por: Abdelnabi, Rana, et al.
Publicado: (2021)

Identification of 2-(4-(Phenylsulfonyl)piperazine-1-yl)pyrimidine Analogues as Novel Inhibitors of Chikungunya Virus
por: Moesslacher, Julia, et al.
Publicado: (2020)

Limited evolution of the yellow fever virus 17d in a mouse infection model
por: Kum, Dieudonné Buh, et al.
Publicado: (2019)

Simple and inexpensive three-step rapid amplification of cDNA 5′ ends using 5′ phosphorylated primers
por: Dallmeier, Kai, et al.
Publicado: (2013)

Zika and Other Emerging Viruses: Aiming at the Right Target
por: Dallmeier, Kai, et al.
Publicado: (2016)

Interaction of LiYF(4):Yb(3+)/Er(3+)/Ho(3+)/Tm(3+)@LiYF(4):Yb(3+) upconversion nanoparticles, molecularly imprinted polymers, and templates
por: Chien, Hsiu-Wen, et al.
Publicado: (2020)

TXGnet: Y.F. Leung’s Functional Genomics
por: Dooley, Erin E.
Publicado: (2004)

Identification of host factors binding to dengue and Zika virus subgenomic RNA by efficient yeast three-hybrid screens of the human ORFeome
por: Jansen, Sander, et al.
Publicado: (2021)

Optimized vaccine candidate MVA-S(3P) fully protects against SARS-CoV-2 infection in hamsters
por: Abdelnabi, Rana, et al.
Publicado: (2023)

Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters, whereas hydroxychloroquine lacks activity
por: Kaptein, Suzanne J. F., et al.
Publicado: (2020)

A chimeric yellow fever-Zika virus vaccine candidate fully protects against yellow fever virus infection in mice
por: Kum, Dieudonné Buh, et al.
Publicado: (2020)

STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters
por: Boudewijns, Robbert, et al.
Publicado: (2020)

MVA-CoV2-S Vaccine Candidate Neutralizes Distinct Variants of Concern and Protects Against SARS-CoV-2 Infection in Hamsters
por: Boudewijns, Robbert, et al.
Publicado: (2022)

Comparing immunogenicity and protective efficacy of the yellow fever 17D vaccine in mice
por: Ma, Ji, et al.
Publicado: (2021)

Antiviral Strategies against Arthritogenic Alphaviruses
por: Abdelnabi, Rana, et al.
Publicado: (2020)

Culex modestus: the overlooked mosquito vector
por: Soto, Alina, et al.
Publicado: (2023)

Nonlinear photoresponse of NaYF(4):Yb,Er@NaYF(4) nanocrystals under green CW excitation: a comprehensive study
por: Ghazyani, Nahid, et al.
Publicado: (2020)

Biodistribution and Biosafety of a Poly(Phosphorhydrazone) Dendrimer, an Anti-Inflammatory Drug-Candidate
por: Fruchon, Séverine, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_cn84hui6dd6fh78r2tc96v6alm