The role of DHCR24 in the pathogenesis of AD: re-cognition of the relationship between cholesterol and AD pathogenesis

Previous studies show that 3β-hydroxysterol-Δ24 reductase (DHCR24) has a remarked decline in the brain of AD patients. In brain cholesterol synthetic metabolism, DHCR24 is known as the heavily key synthetase in cholesterol synthesis. Moreover, mutations of DHCR24 gene result in inhibition of the enz...

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Detalles Bibliográficos
Autores principales: Bai, Xiaojing, Mai, Meiting, Yao, Kai, Zhang, Mengqi, Huang, Yue, Zhang, Wenbin, Guo, Xiaorou, Xu, Yixuan, Zhang, Ying, Qurban, Atikam, Duan, Lijie, Bu, Jimei, Zhang, Jianfeng, Wu, Junfeng, Zhao, Yongfei, Yuan, Xiangshan, Zu, Hengbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8925223/
https://www.ncbi.nlm.nih.gov/pubmed/35296367
http://dx.doi.org/10.1186/s40478-022-01338-3

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