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Radical resection and reconstruction in patients with adenoid cystic carcinoma in the minor salivary glands of the palate

BACKGROUND: This study evaluated the clinical outcomes of the patients with adenoid cystic carcinoma (ACC) of the minor salivary glands of the palate. METHODS: Forty-four patients with stage I–II disease and 14 patients with stage III–IV disease underwent radical excision and reconstruction with a f...

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Autores principales: Chen, Wei-liang, Wang, Yan, Zhou, Bin, Liao, Juan-kun, Chen, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8925237/
https://www.ncbi.nlm.nih.gov/pubmed/35296329
http://dx.doi.org/10.1186/s13005-022-00312-7
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author Chen, Wei-liang
Wang, Yan
Zhou, Bin
Liao, Juan-kun
Chen, Rui
author_facet Chen, Wei-liang
Wang, Yan
Zhou, Bin
Liao, Juan-kun
Chen, Rui
author_sort Chen, Wei-liang
collection PubMed
description BACKGROUND: This study evaluated the clinical outcomes of the patients with adenoid cystic carcinoma (ACC) of the minor salivary glands of the palate. METHODS: Forty-four patients with stage I–II disease and 14 patients with stage III–IV disease underwent radical excision and reconstruction with a facial-submental artery island flap (FSAIF) and titanium mesh plus a free anterolateral thigh flap (ALTF) and radiotherapy respectively. Patients with stage III–IV disease subsequently received cobalt Co 60 adjuvant radiotherapy. Ki-67 expression was determined semiquantitatively in 52 patients with ACC by based on the cytoplasm staining intensity and percentage of positively stained tumor cells. RESULTS: The median (range) follow-up was 32.9 (14–58) months. Forty-one (71.7%) patients survived without disease recurrence. Nine patients (15.5%) survived with recurrent tumors (four with local recurrence, three with regional recurrence requiring salvage surgery, and two with distant metastasis); among these patients, five had overlapping recurrence. Eight patients (13.8%) died of regional, distant, or multiorgan metastasis (range: 22–42 months). The overall median (95% CI) survival time was 32.5 (25.0–39.5) months, and the median (95% CI) progression-free survival time was 32.9 (28.5–36.9) months. Rates of survival and recurrence differed significantly between patients with low- and high-grade tumors, patients with clinical stage I–II disease and those with stage III–IV disease, patients with and without lymph node metastasis, patients who underwent radical excision with versus without radiotherapy, and patients with low and high Ki-67 expression. CONCLUSION: Radical resection and reconstruction with FSAIF is suitable methods for the the treatment of stage I–II ACC of the minor salivary glands of the palate. Stage III–IV tumors require radical resection, reconstruction with titanium mesh and free ALTF, and radiotherapy.
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spelling pubmed-89252372022-03-23 Radical resection and reconstruction in patients with adenoid cystic carcinoma in the minor salivary glands of the palate Chen, Wei-liang Wang, Yan Zhou, Bin Liao, Juan-kun Chen, Rui Head Face Med Research BACKGROUND: This study evaluated the clinical outcomes of the patients with adenoid cystic carcinoma (ACC) of the minor salivary glands of the palate. METHODS: Forty-four patients with stage I–II disease and 14 patients with stage III–IV disease underwent radical excision and reconstruction with a facial-submental artery island flap (FSAIF) and titanium mesh plus a free anterolateral thigh flap (ALTF) and radiotherapy respectively. Patients with stage III–IV disease subsequently received cobalt Co 60 adjuvant radiotherapy. Ki-67 expression was determined semiquantitatively in 52 patients with ACC by based on the cytoplasm staining intensity and percentage of positively stained tumor cells. RESULTS: The median (range) follow-up was 32.9 (14–58) months. Forty-one (71.7%) patients survived without disease recurrence. Nine patients (15.5%) survived with recurrent tumors (four with local recurrence, three with regional recurrence requiring salvage surgery, and two with distant metastasis); among these patients, five had overlapping recurrence. Eight patients (13.8%) died of regional, distant, or multiorgan metastasis (range: 22–42 months). The overall median (95% CI) survival time was 32.5 (25.0–39.5) months, and the median (95% CI) progression-free survival time was 32.9 (28.5–36.9) months. Rates of survival and recurrence differed significantly between patients with low- and high-grade tumors, patients with clinical stage I–II disease and those with stage III–IV disease, patients with and without lymph node metastasis, patients who underwent radical excision with versus without radiotherapy, and patients with low and high Ki-67 expression. CONCLUSION: Radical resection and reconstruction with FSAIF is suitable methods for the the treatment of stage I–II ACC of the minor salivary glands of the palate. Stage III–IV tumors require radical resection, reconstruction with titanium mesh and free ALTF, and radiotherapy. BioMed Central 2022-03-16 /pmc/articles/PMC8925237/ /pubmed/35296329 http://dx.doi.org/10.1186/s13005-022-00312-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Chen, Wei-liang
Wang, Yan
Zhou, Bin
Liao, Juan-kun
Chen, Rui
Radical resection and reconstruction in patients with adenoid cystic carcinoma in the minor salivary glands of the palate
title Radical resection and reconstruction in patients with adenoid cystic carcinoma in the minor salivary glands of the palate
title_full Radical resection and reconstruction in patients with adenoid cystic carcinoma in the minor salivary glands of the palate
title_fullStr Radical resection and reconstruction in patients with adenoid cystic carcinoma in the minor salivary glands of the palate
title_full_unstemmed Radical resection and reconstruction in patients with adenoid cystic carcinoma in the minor salivary glands of the palate
title_short Radical resection and reconstruction in patients with adenoid cystic carcinoma in the minor salivary glands of the palate
title_sort radical resection and reconstruction in patients with adenoid cystic carcinoma in the minor salivary glands of the palate
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8925237/
https://www.ncbi.nlm.nih.gov/pubmed/35296329
http://dx.doi.org/10.1186/s13005-022-00312-7
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