Computational approaches towards the discovery and optimisation of cruzain inhibitors

The need to develop safer and more efficacious drugs to treat Chagas disease has motivated the search for cruzain inhibitors. Cruzain is the recombinant, truncated version of cruzipain, a cysteine protease from Trypanosoma cruzi with important roles during the parasite life cycle. Several computatio...

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Detalles Bibliográficos
Autores principales: Santos, Viviane Corrêa, Ferreira, Rafaela Salgado
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2022
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8925305/
https://www.ncbi.nlm.nih.gov/pubmed/35293427
http://dx.doi.org/10.1590/0074-02760210385

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8925305/
https://www.ncbi.nlm.nih.gov/pubmed/35293427
http://dx.doi.org/10.1590/0074-02760210385

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