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Computational approaches towards the discovery and optimisation of cruzain inhibitors
The need to develop safer and more efficacious drugs to treat Chagas disease has motivated the search for cruzain inhibitors. Cruzain is the recombinant, truncated version of cruzipain, a cysteine protease from Trypanosoma cruzi with important roles during the parasite life cycle. Several computatio...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Instituto Oswaldo Cruz, Ministério da Saúde
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8925305/ https://www.ncbi.nlm.nih.gov/pubmed/35293427 http://dx.doi.org/10.1590/0074-02760210385 |