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Helicobacter pylori infection and iron deficiency in non-elderly adults participating in a health check-up program

BACKGROUND/AIMS: Helicobacter pylori infection is presumably associated with iron deficiency and iron deficiency anemia (IDA). This study aimed to evaluate the relationship between H. pylori infection and the decline in iron stores in non-elderly adults during their health check-ups. METHODS: We ide...

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Autores principales: Lee, Jun Yeop, Kim, Sung Eun, Park, Seun Ja, Park, Moo In, Moon, Won, Kim, Jae Hyun, Jung, Kyoungwon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association of Internal Medicine 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8925964/
https://www.ncbi.nlm.nih.gov/pubmed/34905815
http://dx.doi.org/10.3904/kjim.2020.433
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author Lee, Jun Yeop
Kim, Sung Eun
Park, Seun Ja
Park, Moo In
Moon, Won
Kim, Jae Hyun
Jung, Kyoungwon
author_facet Lee, Jun Yeop
Kim, Sung Eun
Park, Seun Ja
Park, Moo In
Moon, Won
Kim, Jae Hyun
Jung, Kyoungwon
author_sort Lee, Jun Yeop
collection PubMed
description BACKGROUND/AIMS: Helicobacter pylori infection is presumably associated with iron deficiency and iron deficiency anemia (IDA). This study aimed to evaluate the relationship between H. pylori infection and the decline in iron stores in non-elderly adults during their health check-ups. METHODS: We identified a total of 1,069 subjects who were tested for iron, ferritin, and total iron-binding capacity during their health check-ups, from January 2016 to May 2017. Of these, subjects who underwent endoscopy via rapid urease test and those aged 65 years or below were finally enrolled. RESULTS: Overall, 281 subjects were enrolled, and 187 patients (66.5%) tested positive for H. pylori. The mean age was 36.1 years (range, 22 to 65), and 176 subjects (62.6%) were male. The mean levels of hemoglobin (14.1 ± 1.7 g/dL vs. 14.6 ± 1.4 g/dL, p = 0.019) and ferritin (121.7 ± 106.9 ng/mL vs. 151.8 ± 107.8 ng/mL, p = 0.027) in the H. pylori-positive group were significantly lower than those in the H. pylori-negative group. Iron deficiency (ferritin < 30 ng/mL) was more common in patients with H. pylori infection (p = 0.002). There was no significant difference in anemia (hemoglobin < 13 g/dL in men, < 12 g/dL in women) or IDA (anemia, ferritin < 10 ng/mL, and transferrin saturation < 16%) with H. pylori. Logistic regression analysis demonstrated that female sex (odds ratio, 197.559; 95% confidence interval, 26.461 to 1,475.015) and H. pylori infection (odds ratio, 3.033; 95% confidence interval, 1.216 to 7.567) were factors associated with iron deficiency. CONCLUSIONS: H. pylori infection is associated with iron deficiency, suggesting a decline in iron stores among infected non-elderly adults.
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spelling pubmed-89259642022-03-24 Helicobacter pylori infection and iron deficiency in non-elderly adults participating in a health check-up program Lee, Jun Yeop Kim, Sung Eun Park, Seun Ja Park, Moo In Moon, Won Kim, Jae Hyun Jung, Kyoungwon Korean J Intern Med Original Article BACKGROUND/AIMS: Helicobacter pylori infection is presumably associated with iron deficiency and iron deficiency anemia (IDA). This study aimed to evaluate the relationship between H. pylori infection and the decline in iron stores in non-elderly adults during their health check-ups. METHODS: We identified a total of 1,069 subjects who were tested for iron, ferritin, and total iron-binding capacity during their health check-ups, from January 2016 to May 2017. Of these, subjects who underwent endoscopy via rapid urease test and those aged 65 years or below were finally enrolled. RESULTS: Overall, 281 subjects were enrolled, and 187 patients (66.5%) tested positive for H. pylori. The mean age was 36.1 years (range, 22 to 65), and 176 subjects (62.6%) were male. The mean levels of hemoglobin (14.1 ± 1.7 g/dL vs. 14.6 ± 1.4 g/dL, p = 0.019) and ferritin (121.7 ± 106.9 ng/mL vs. 151.8 ± 107.8 ng/mL, p = 0.027) in the H. pylori-positive group were significantly lower than those in the H. pylori-negative group. Iron deficiency (ferritin < 30 ng/mL) was more common in patients with H. pylori infection (p = 0.002). There was no significant difference in anemia (hemoglobin < 13 g/dL in men, < 12 g/dL in women) or IDA (anemia, ferritin < 10 ng/mL, and transferrin saturation < 16%) with H. pylori. Logistic regression analysis demonstrated that female sex (odds ratio, 197.559; 95% confidence interval, 26.461 to 1,475.015) and H. pylori infection (odds ratio, 3.033; 95% confidence interval, 1.216 to 7.567) were factors associated with iron deficiency. CONCLUSIONS: H. pylori infection is associated with iron deficiency, suggesting a decline in iron stores among infected non-elderly adults. Korean Association of Internal Medicine 2022-03 2021-12-16 /pmc/articles/PMC8925964/ /pubmed/34905815 http://dx.doi.org/10.3904/kjim.2020.433 Text en Copyright © 2022 The Korean Association of Internal Medicine https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lee, Jun Yeop
Kim, Sung Eun
Park, Seun Ja
Park, Moo In
Moon, Won
Kim, Jae Hyun
Jung, Kyoungwon
Helicobacter pylori infection and iron deficiency in non-elderly adults participating in a health check-up program
title Helicobacter pylori infection and iron deficiency in non-elderly adults participating in a health check-up program
title_full Helicobacter pylori infection and iron deficiency in non-elderly adults participating in a health check-up program
title_fullStr Helicobacter pylori infection and iron deficiency in non-elderly adults participating in a health check-up program
title_full_unstemmed Helicobacter pylori infection and iron deficiency in non-elderly adults participating in a health check-up program
title_short Helicobacter pylori infection and iron deficiency in non-elderly adults participating in a health check-up program
title_sort helicobacter pylori infection and iron deficiency in non-elderly adults participating in a health check-up program
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8925964/
https://www.ncbi.nlm.nih.gov/pubmed/34905815
http://dx.doi.org/10.3904/kjim.2020.433
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