An integrated platform approach enables discovery of potent, selective and ligand-competitive cyclic peptides targeting the GIP receptor

In any drug discovery effort, the identification of hits for further optimisation is of crucial importance. For peptide therapeutics, display technologies such as mRNA display have emerged as powerful methodologies to identify these desired de novo hit ligands against targets of interest. The divers...

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Detalles Bibliográficos
Autores principales: Bhushan, Bhaskar, Granata, Daniele, Kaas, Christian S., Kasimova, Marina A., Ren, Qiansheng, Cramer, Christian N., White, Mark D., Hansen, Ann Maria K., Fledelius, Christian, Invernizzi, Gaetano, Deibler, Kristine, Coleman, Oliver D., Zhao, Xin, Qu, Xinping, Liu, Haimo, Zurmühl, Silvana S., Kodra, Janos T., Kawamura, Akane, Münzel, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8926291/
https://www.ncbi.nlm.nih.gov/pubmed/35414877
http://dx.doi.org/10.1039/d1sc06844j

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