Iridium-catalyzed asymmetric trans-selective hydrogenation of 1,3-disubstituted isoquinolines

The development of the first asymmetric trans-selective hydrogenation of 1,3-disubstituted isoquinolines is reported. Utilizing [Ir(cod)Cl](2) and a commercially available chiral Josiphos ligand, a variety of differentially substituted isoquinolines are hydrogenated to produce enantioenriched trans-...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Alexia N., Ngamnithiporn, Aurapat, Bartberger, Michael D., Stoltz, Brian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8926345/
https://www.ncbi.nlm.nih.gov/pubmed/35414874
http://dx.doi.org/10.1039/d1sc06729j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8926345/
https://www.ncbi.nlm.nih.gov/pubmed/35414874
http://dx.doi.org/10.1039/d1sc06729j

Ejemplares similares