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Iridium-catalyzed asymmetric trans-selective hydrogenation of 1,3-disubstituted isoquinolines

The development of the first asymmetric trans-selective hydrogenation of 1,3-disubstituted isoquinolines is reported. Utilizing [Ir(cod)Cl](2) and a commercially available chiral Josiphos ligand, a variety of differentially substituted isoquinolines are hydrogenated to produce enantioenriched trans-...

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Detalles Bibliográficos
Autores principales:	Kim, Alexia N., Ngamnithiporn, Aurapat, Bartberger, Michael D., Stoltz, Brian M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8926345/ https://www.ncbi.nlm.nih.gov/pubmed/35414874 http://dx.doi.org/10.1039/d1sc06729j

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