Global and context-specific transcriptional consequences of oncogenic Fbw7 mutations

The Fbw7 ubiquitin ligase targets many proteins for proteasomal degradation, which include oncogenic transcription factors (TFs) (e.g., c-Myc, c-Jun, and Notch). Fbw7 is a tumor suppressor and tumors often contain mutations in FBXW7, the gene that encodes Fbw7. The complexity of its substrate networ...

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Detalles Bibliográficos
Autores principales: Thirimanne, H Nayanga, Wu, Feinan, Janssens, Derek H, Swanger, Jherek, Diab, Ahmed, Feldman, Heather M, Amezquita, Robert A, Gottardo, Raphael, Paddison, Patrick J, Henikoff, Steven, Clurman, Bruce E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8926403/
https://www.ncbi.nlm.nih.gov/pubmed/35225231
http://dx.doi.org/10.7554/eLife.74338

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8926403/
https://www.ncbi.nlm.nih.gov/pubmed/35225231
http://dx.doi.org/10.7554/eLife.74338

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