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A Novel Pyrazolo[3,4-d]pyrimidine Induces Heme Oxygenase-1 and Exerts Anti-Inflammatory and Neuroprotective Effects

The anti-oxidant enzyme heme oxygenase-1 (HO-1) is known to exert anti-inflammatory effects. From a library of pyrazolo[3,4-d]pyrimidines, we identified a novel compound KKC080096 that upregulated HO-1 at the mRNA and protein levels in microglial BV-2 cells. KKC080096 exhibited anti-inflammatory eff...

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Detalles Bibliográficos
Autores principales:	Lee, Ji Ae, Kwon, Young-Won, Kim, Hye Ri, Shin, Nari, Son, Hyo Jin, Cheong, Chan Seong, Kim, Dong Jin, Hwang, Onyou
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Molecular and Cellular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8926863/ https://www.ncbi.nlm.nih.gov/pubmed/34887364 http://dx.doi.org/10.14348/molcells.2021.0074

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