A novel nano‐immunotherapeutic remodels the immune landscape of malignant pleural effusion: Insights into its mechanism of action through single‐cell RNA‐sequencing

Clinical evidence indicates that the microenvironment in malignant pleural effusion (MPE) is immunologically cold, which impairs tumour immunosurveillance and antitumor immune response to immune checkpoint blockade (ICB). In a recent issue of Nature Nanotechnology, Liu et al. demonstrate a new nanot...

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Detalles Bibliográficos
Autores principales: Liu, Yang, Zhao, Dawen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8926894/
https://www.ncbi.nlm.nih.gov/pubmed/35297203
http://dx.doi.org/10.1002/ctm2.774
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author Liu, Yang
Zhao, Dawen
author_facet Liu, Yang
Zhao, Dawen
author_sort Liu, Yang
collection PubMed
description Clinical evidence indicates that the microenvironment in malignant pleural effusion (MPE) is immunologically cold, which impairs tumour immunosurveillance and antitumor immune response to immune checkpoint blockade (ICB). In a recent issue of Nature Nanotechnology, Liu et al. demonstrate a new nanotechnological approach to effectively mitigate the immune cold MPE and provide insights into its mechanism of action through single‐cell RNA‐sequencing.
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spelling pubmed-89268942022-03-24 A novel nano‐immunotherapeutic remodels the immune landscape of malignant pleural effusion: Insights into its mechanism of action through single‐cell RNA‐sequencing Liu, Yang Zhao, Dawen Clin Transl Med Editorial Clinical evidence indicates that the microenvironment in malignant pleural effusion (MPE) is immunologically cold, which impairs tumour immunosurveillance and antitumor immune response to immune checkpoint blockade (ICB). In a recent issue of Nature Nanotechnology, Liu et al. demonstrate a new nanotechnological approach to effectively mitigate the immune cold MPE and provide insights into its mechanism of action through single‐cell RNA‐sequencing. John Wiley and Sons Inc. 2022-03-16 /pmc/articles/PMC8926894/ /pubmed/35297203 http://dx.doi.org/10.1002/ctm2.774 Text en © 2022 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Editorial
Liu, Yang
Zhao, Dawen
A novel nano‐immunotherapeutic remodels the immune landscape of malignant pleural effusion: Insights into its mechanism of action through single‐cell RNA‐sequencing
title A novel nano‐immunotherapeutic remodels the immune landscape of malignant pleural effusion: Insights into its mechanism of action through single‐cell RNA‐sequencing
title_full A novel nano‐immunotherapeutic remodels the immune landscape of malignant pleural effusion: Insights into its mechanism of action through single‐cell RNA‐sequencing
title_fullStr A novel nano‐immunotherapeutic remodels the immune landscape of malignant pleural effusion: Insights into its mechanism of action through single‐cell RNA‐sequencing
title_full_unstemmed A novel nano‐immunotherapeutic remodels the immune landscape of malignant pleural effusion: Insights into its mechanism of action through single‐cell RNA‐sequencing
title_short A novel nano‐immunotherapeutic remodels the immune landscape of malignant pleural effusion: Insights into its mechanism of action through single‐cell RNA‐sequencing
title_sort novel nano‐immunotherapeutic remodels the immune landscape of malignant pleural effusion: insights into its mechanism of action through single‐cell rna‐sequencing
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8926894/
https://www.ncbi.nlm.nih.gov/pubmed/35297203
http://dx.doi.org/10.1002/ctm2.774
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