Progressive pulmonary fibrosis due to diffuse alveolar damage in a COVID‐19‐infected autopsy case

We encountered a patient with severe coronavirus disease 2019 (COVID‐19)‐related pneumonia, who died of progressive respiratory acidosis after 2 months of treatment with mechanical ventilation. The autopsy revealed diffuse alveolar damage (DAD) without any active signs of fungal or bacterial infecti...

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Detalles Bibliográficos
Autores principales: Tamura, Akiko, Imai, Ryosuke, Tomishima, Yutaka, Nishimura, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2022
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8926900/
https://www.ncbi.nlm.nih.gov/pubmed/35342636
http://dx.doi.org/10.1002/rcr2.934
Descripción
Sumario:We encountered a patient with severe coronavirus disease 2019 (COVID‐19)‐related pneumonia, who died of progressive respiratory acidosis after 2 months of treatment with mechanical ventilation. The autopsy revealed diffuse alveolar damage (DAD) without any active signs of fungal or bacterial infections, suggesting prolonged and over‐activated immune responses against COVID‐19 infection. When COVID‐19 patients develop acute respiratory distress syndrome, it is essential to remember that the infection can progress to DAD a few months after the disease onset.

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