Progressive pulmonary fibrosis due to diffuse alveolar damage in a COVID‐19‐infected autopsy case

We encountered a patient with severe coronavirus disease 2019 (COVID‐19)‐related pneumonia, who died of progressive respiratory acidosis after 2 months of treatment with mechanical ventilation. The autopsy revealed diffuse alveolar damage (DAD) without any active signs of fungal or bacterial infecti...

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Autores principales: Tamura, Akiko, Imai, Ryosuke, Tomishima, Yutaka, Nishimura, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2022
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8926900/
https://www.ncbi.nlm.nih.gov/pubmed/35342636
http://dx.doi.org/10.1002/rcr2.934
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author Tamura, Akiko
Imai, Ryosuke
Tomishima, Yutaka
Nishimura, Naoki
author_facet Tamura, Akiko
Imai, Ryosuke
Tomishima, Yutaka
Nishimura, Naoki
author_sort Tamura, Akiko
collection PubMed
description We encountered a patient with severe coronavirus disease 2019 (COVID‐19)‐related pneumonia, who died of progressive respiratory acidosis after 2 months of treatment with mechanical ventilation. The autopsy revealed diffuse alveolar damage (DAD) without any active signs of fungal or bacterial infections, suggesting prolonged and over‐activated immune responses against COVID‐19 infection. When COVID‐19 patients develop acute respiratory distress syndrome, it is essential to remember that the infection can progress to DAD a few months after the disease onset.
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spelling pubmed-89269002022-03-24 Progressive pulmonary fibrosis due to diffuse alveolar damage in a COVID‐19‐infected autopsy case Tamura, Akiko Imai, Ryosuke Tomishima, Yutaka Nishimura, Naoki Respirol Case Rep Case Reports We encountered a patient with severe coronavirus disease 2019 (COVID‐19)‐related pneumonia, who died of progressive respiratory acidosis after 2 months of treatment with mechanical ventilation. The autopsy revealed diffuse alveolar damage (DAD) without any active signs of fungal or bacterial infections, suggesting prolonged and over‐activated immune responses against COVID‐19 infection. When COVID‐19 patients develop acute respiratory distress syndrome, it is essential to remember that the infection can progress to DAD a few months after the disease onset. John Wiley & Sons, Ltd 2022-03-16 /pmc/articles/PMC8926900/ /pubmed/35342636 http://dx.doi.org/10.1002/rcr2.934 Text en © 2022 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Tamura, Akiko
Imai, Ryosuke
Tomishima, Yutaka
Nishimura, Naoki
Progressive pulmonary fibrosis due to diffuse alveolar damage in a COVID‐19‐infected autopsy case
title Progressive pulmonary fibrosis due to diffuse alveolar damage in a COVID‐19‐infected autopsy case
title_full Progressive pulmonary fibrosis due to diffuse alveolar damage in a COVID‐19‐infected autopsy case
title_fullStr Progressive pulmonary fibrosis due to diffuse alveolar damage in a COVID‐19‐infected autopsy case
title_full_unstemmed Progressive pulmonary fibrosis due to diffuse alveolar damage in a COVID‐19‐infected autopsy case
title_short Progressive pulmonary fibrosis due to diffuse alveolar damage in a COVID‐19‐infected autopsy case
title_sort progressive pulmonary fibrosis due to diffuse alveolar damage in a covid‐19‐infected autopsy case
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8926900/
https://www.ncbi.nlm.nih.gov/pubmed/35342636
http://dx.doi.org/10.1002/rcr2.934
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