Cargando…
Population genomic analysis of Aegilops tauschii identifies targets for bread wheat improvement
Aegilops tauschii, the diploid wild progenitor of the D subgenome of bread wheat, is a reservoir of genetic diversity for improving bread wheat performance and environmental resilience. Here we sequenced 242 Ae. tauschii accessions and compared them to the wheat D subgenome to characterize genomic d...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group US
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8926922/ https://www.ncbi.nlm.nih.gov/pubmed/34725503 http://dx.doi.org/10.1038/s41587-021-01058-4 |
_version_ | 1784670338413494272 |
---|---|
author | Gaurav, Kumar Arora, Sanu Silva, Paula Sánchez-Martín, Javier Horsnell, Richard Gao, Liangliang Brar, Gurcharn S. Widrig, Victoria John Raupp, W. Singh, Narinder Wu, Shuangye Kale, Sandip M. Chinoy, Catherine Nicholson, Paul Quiroz-Chávez, Jesús Simmonds, James Hayta, Sadiye Smedley, Mark A. Harwood, Wendy Pearce, Suzannah Gilbert, David Kangara, Ngonidzashe Gardener, Catherine Forner-Martínez, Macarena Liu, Jiaqian Yu, Guotai Boden, Scott A. Pascucci, Attilio Ghosh, Sreya Hafeez, Amber N. O’Hara, Tom Waites, Joshua Cheema, Jitender Steuernagel, Burkhard Patpour, Mehran Justesen, Annemarie Fejer Liu, Shuyu Rudd, Jackie C. Avni, Raz Sharon, Amir Steiner, Barbara Kirana, Rizky Pasthika Buerstmayr, Hermann Mehrabi, Ali A. Nasyrova, Firuza Y. Chayut, Noam Matny, Oadi Steffenson, Brian J. Sandhu, Nitika Chhuneja, Parveen Lagudah, Evans Elkot, Ahmed F. Tyrrell, Simon Bian, Xingdong Davey, Robert P. Simonsen, Martin Schauser, Leif Tiwari, Vijay K. Randy Kutcher, H. Hucl, Pierre Li, Aili Liu, Deng-Cai Mao, Long Xu, Steven Brown-Guedira, Gina Faris, Justin Dvorak, Jan Luo, Ming-Cheng Krasileva, Ksenia Lux, Thomas Artmeier, Susanne Mayer, Klaus F. X. Uauy, Cristobal Mascher, Martin Bentley, Alison R. Keller, Beat Poland, Jesse Wulff, Brande B. H. |
author_facet | Gaurav, Kumar Arora, Sanu Silva, Paula Sánchez-Martín, Javier Horsnell, Richard Gao, Liangliang Brar, Gurcharn S. Widrig, Victoria John Raupp, W. Singh, Narinder Wu, Shuangye Kale, Sandip M. Chinoy, Catherine Nicholson, Paul Quiroz-Chávez, Jesús Simmonds, James Hayta, Sadiye Smedley, Mark A. Harwood, Wendy Pearce, Suzannah Gilbert, David Kangara, Ngonidzashe Gardener, Catherine Forner-Martínez, Macarena Liu, Jiaqian Yu, Guotai Boden, Scott A. Pascucci, Attilio Ghosh, Sreya Hafeez, Amber N. O’Hara, Tom Waites, Joshua Cheema, Jitender Steuernagel, Burkhard Patpour, Mehran Justesen, Annemarie Fejer Liu, Shuyu Rudd, Jackie C. Avni, Raz Sharon, Amir Steiner, Barbara Kirana, Rizky Pasthika Buerstmayr, Hermann Mehrabi, Ali A. Nasyrova, Firuza Y. Chayut, Noam Matny, Oadi Steffenson, Brian J. Sandhu, Nitika Chhuneja, Parveen Lagudah, Evans Elkot, Ahmed F. Tyrrell, Simon Bian, Xingdong Davey, Robert P. Simonsen, Martin Schauser, Leif Tiwari, Vijay K. Randy Kutcher, H. Hucl, Pierre Li, Aili Liu, Deng-Cai Mao, Long Xu, Steven Brown-Guedira, Gina Faris, Justin Dvorak, Jan Luo, Ming-Cheng Krasileva, Ksenia Lux, Thomas Artmeier, Susanne Mayer, Klaus F. X. Uauy, Cristobal Mascher, Martin Bentley, Alison R. Keller, Beat Poland, Jesse Wulff, Brande B. H. |
author_sort | Gaurav, Kumar |
collection | PubMed |
description | Aegilops tauschii, the diploid wild progenitor of the D subgenome of bread wheat, is a reservoir of genetic diversity for improving bread wheat performance and environmental resilience. Here we sequenced 242 Ae. tauschii accessions and compared them to the wheat D subgenome to characterize genomic diversity. We found that a rare lineage of Ae. tauschii geographically restricted to present-day Georgia contributed to the wheat D subgenome in the independent hybridizations that gave rise to modern bread wheat. Through k-mer-based association mapping, we identified discrete genomic regions with candidate genes for disease and pest resistance and demonstrated their functional transfer into wheat by transgenesis and wide crossing, including the generation of a library of hexaploids incorporating diverse Ae. tauschii genomes. Exploiting the genomic diversity of the Ae. tauschii ancestral diploid genome permits rapid trait discovery and functional genetic validation in a hexaploid background amenable to breeding. |
format | Online Article Text |
id | pubmed-8926922 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group US |
record_format | MEDLINE/PubMed |
spelling | pubmed-89269222022-04-01 Population genomic analysis of Aegilops tauschii identifies targets for bread wheat improvement Gaurav, Kumar Arora, Sanu Silva, Paula Sánchez-Martín, Javier Horsnell, Richard Gao, Liangliang Brar, Gurcharn S. Widrig, Victoria John Raupp, W. Singh, Narinder Wu, Shuangye Kale, Sandip M. Chinoy, Catherine Nicholson, Paul Quiroz-Chávez, Jesús Simmonds, James Hayta, Sadiye Smedley, Mark A. Harwood, Wendy Pearce, Suzannah Gilbert, David Kangara, Ngonidzashe Gardener, Catherine Forner-Martínez, Macarena Liu, Jiaqian Yu, Guotai Boden, Scott A. Pascucci, Attilio Ghosh, Sreya Hafeez, Amber N. O’Hara, Tom Waites, Joshua Cheema, Jitender Steuernagel, Burkhard Patpour, Mehran Justesen, Annemarie Fejer Liu, Shuyu Rudd, Jackie C. Avni, Raz Sharon, Amir Steiner, Barbara Kirana, Rizky Pasthika Buerstmayr, Hermann Mehrabi, Ali A. Nasyrova, Firuza Y. Chayut, Noam Matny, Oadi Steffenson, Brian J. Sandhu, Nitika Chhuneja, Parveen Lagudah, Evans Elkot, Ahmed F. Tyrrell, Simon Bian, Xingdong Davey, Robert P. Simonsen, Martin Schauser, Leif Tiwari, Vijay K. Randy Kutcher, H. Hucl, Pierre Li, Aili Liu, Deng-Cai Mao, Long Xu, Steven Brown-Guedira, Gina Faris, Justin Dvorak, Jan Luo, Ming-Cheng Krasileva, Ksenia Lux, Thomas Artmeier, Susanne Mayer, Klaus F. X. Uauy, Cristobal Mascher, Martin Bentley, Alison R. Keller, Beat Poland, Jesse Wulff, Brande B. H. Nat Biotechnol Article Aegilops tauschii, the diploid wild progenitor of the D subgenome of bread wheat, is a reservoir of genetic diversity for improving bread wheat performance and environmental resilience. Here we sequenced 242 Ae. tauschii accessions and compared them to the wheat D subgenome to characterize genomic diversity. We found that a rare lineage of Ae. tauschii geographically restricted to present-day Georgia contributed to the wheat D subgenome in the independent hybridizations that gave rise to modern bread wheat. Through k-mer-based association mapping, we identified discrete genomic regions with candidate genes for disease and pest resistance and demonstrated their functional transfer into wheat by transgenesis and wide crossing, including the generation of a library of hexaploids incorporating diverse Ae. tauschii genomes. Exploiting the genomic diversity of the Ae. tauschii ancestral diploid genome permits rapid trait discovery and functional genetic validation in a hexaploid background amenable to breeding. Nature Publishing Group US 2021-11-01 2022 /pmc/articles/PMC8926922/ /pubmed/34725503 http://dx.doi.org/10.1038/s41587-021-01058-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Gaurav, Kumar Arora, Sanu Silva, Paula Sánchez-Martín, Javier Horsnell, Richard Gao, Liangliang Brar, Gurcharn S. Widrig, Victoria John Raupp, W. Singh, Narinder Wu, Shuangye Kale, Sandip M. Chinoy, Catherine Nicholson, Paul Quiroz-Chávez, Jesús Simmonds, James Hayta, Sadiye Smedley, Mark A. Harwood, Wendy Pearce, Suzannah Gilbert, David Kangara, Ngonidzashe Gardener, Catherine Forner-Martínez, Macarena Liu, Jiaqian Yu, Guotai Boden, Scott A. Pascucci, Attilio Ghosh, Sreya Hafeez, Amber N. O’Hara, Tom Waites, Joshua Cheema, Jitender Steuernagel, Burkhard Patpour, Mehran Justesen, Annemarie Fejer Liu, Shuyu Rudd, Jackie C. Avni, Raz Sharon, Amir Steiner, Barbara Kirana, Rizky Pasthika Buerstmayr, Hermann Mehrabi, Ali A. Nasyrova, Firuza Y. Chayut, Noam Matny, Oadi Steffenson, Brian J. Sandhu, Nitika Chhuneja, Parveen Lagudah, Evans Elkot, Ahmed F. Tyrrell, Simon Bian, Xingdong Davey, Robert P. Simonsen, Martin Schauser, Leif Tiwari, Vijay K. Randy Kutcher, H. Hucl, Pierre Li, Aili Liu, Deng-Cai Mao, Long Xu, Steven Brown-Guedira, Gina Faris, Justin Dvorak, Jan Luo, Ming-Cheng Krasileva, Ksenia Lux, Thomas Artmeier, Susanne Mayer, Klaus F. X. Uauy, Cristobal Mascher, Martin Bentley, Alison R. Keller, Beat Poland, Jesse Wulff, Brande B. H. Population genomic analysis of Aegilops tauschii identifies targets for bread wheat improvement |
title | Population genomic analysis of Aegilops tauschii identifies targets for bread wheat improvement |
title_full | Population genomic analysis of Aegilops tauschii identifies targets for bread wheat improvement |
title_fullStr | Population genomic analysis of Aegilops tauschii identifies targets for bread wheat improvement |
title_full_unstemmed | Population genomic analysis of Aegilops tauschii identifies targets for bread wheat improvement |
title_short | Population genomic analysis of Aegilops tauschii identifies targets for bread wheat improvement |
title_sort | population genomic analysis of aegilops tauschii identifies targets for bread wheat improvement |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8926922/ https://www.ncbi.nlm.nih.gov/pubmed/34725503 http://dx.doi.org/10.1038/s41587-021-01058-4 |
work_keys_str_mv | AT gauravkumar populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT arorasanu populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT silvapaula populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT sanchezmartinjavier populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT horsnellrichard populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT gaoliangliang populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT brargurcharns populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT widrigvictoria populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT johnrauppw populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT singhnarinder populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT wushuangye populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT kalesandipm populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT chinoycatherine populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT nicholsonpaul populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT quirozchavezjesus populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT simmondsjames populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT haytasadiye populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT smedleymarka populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT harwoodwendy populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT pearcesuzannah populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT gilbertdavid populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT kangarangonidzashe populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT gardenercatherine populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT fornermartinezmacarena populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT liujiaqian populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT yuguotai populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT bodenscotta populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT pascucciattilio populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT ghoshsreya populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT hafeezambern populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT oharatom populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT waitesjoshua populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT cheemajitender populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT steuernagelburkhard populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT patpourmehran populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT justesenannemariefejer populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT liushuyu populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT ruddjackiec populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT avniraz populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT sharonamir populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT steinerbarbara populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT kiranarizkypasthika populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT buerstmayrhermann populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT mehrabialia populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT nasyrovafiruzay populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT chayutnoam populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT matnyoadi populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT steffensonbrianj populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT sandhunitika populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT chhunejaparveen populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT lagudahevans populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT elkotahmedf populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT tyrrellsimon populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT bianxingdong populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT daveyrobertp populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT simonsenmartin populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT schauserleif populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT tiwarivijayk populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT randykutcherh populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT huclpierre populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT liaili populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT liudengcai populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT maolong populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT xusteven populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT brownguediragina populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT farisjustin populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT dvorakjan populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT luomingcheng populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT krasilevaksenia populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT luxthomas populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT artmeiersusanne populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT mayerklausfx populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT uauycristobal populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT maschermartin populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT bentleyalisonr populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT kellerbeat populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT polandjesse populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement AT wulffbrandebh populationgenomicanalysisofaegilopstauschiiidentifiestargetsforbreadwheatimprovement |