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Protein tau concentration in blood increases after SCUBA diving: an observational study

PURPOSE: It is speculated that diving might be harmful to the nervous system. The aim of this study was to determine if established markers of neuronal injury were increased in the blood after diving. METHODS: Thirty-two divers performed two identical dives, 48 h apart, in a water-filled hyperbaric...

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Autores principales: Rosén, Anders, Gennser, Mikael, Oscarsson, Nicklas, Kvarnström, Andreas, Sandström, Göran, Seeman-Lodding, Helen, Simrén, Joel, Zetterberg, Henrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8926952/
https://www.ncbi.nlm.nih.gov/pubmed/35142945
http://dx.doi.org/10.1007/s00421-022-04892-9
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author Rosén, Anders
Gennser, Mikael
Oscarsson, Nicklas
Kvarnström, Andreas
Sandström, Göran
Seeman-Lodding, Helen
Simrén, Joel
Zetterberg, Henrik
author_facet Rosén, Anders
Gennser, Mikael
Oscarsson, Nicklas
Kvarnström, Andreas
Sandström, Göran
Seeman-Lodding, Helen
Simrén, Joel
Zetterberg, Henrik
author_sort Rosén, Anders
collection PubMed
description PURPOSE: It is speculated that diving might be harmful to the nervous system. The aim of this study was to determine if established markers of neuronal injury were increased in the blood after diving. METHODS: Thirty-two divers performed two identical dives, 48 h apart, in a water-filled hyperbaric chamber pressurized to an equivalent of 42 m of sea water for 10 min. After one of the two dives, normobaric oxygen was breathed for 30 min, with air breathed after the other. Blood samples were obtained before and at 30–45 and 120 min after diving. Concentrations of glial fibrillary acidic, neurofilament light, and tau proteins were measured using single molecule array technology. Doppler ultrasound was used to detect venous gas emboli. RESULTS: Tau was significantly increased at 30–45 min after the second dive (p < 0.0098) and at 120 min after both dives (p < 0.0008/p < 0.0041). Comparison of matching samples showed that oxygen breathing after diving did not influence tau results. There was no correlation between tau concentrations and the presence of venous gas emboli. Glial fibrillary acidic protein was decreased 30–45 min after the first dive but at no other point. Neurofilament light concentrations did not change. CONCLUSIONS: Tau seems to be a promising marker of dive-related neuronal stress, which is independent of the presence of venous gas emboli. Future studies could validate these results and determine if there is a quantitative relationship between dive exposure and change in tau blood concentration. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00421-022-04892-9.
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spelling pubmed-89269522022-03-22 Protein tau concentration in blood increases after SCUBA diving: an observational study Rosén, Anders Gennser, Mikael Oscarsson, Nicklas Kvarnström, Andreas Sandström, Göran Seeman-Lodding, Helen Simrén, Joel Zetterberg, Henrik Eur J Appl Physiol Original Article PURPOSE: It is speculated that diving might be harmful to the nervous system. The aim of this study was to determine if established markers of neuronal injury were increased in the blood after diving. METHODS: Thirty-two divers performed two identical dives, 48 h apart, in a water-filled hyperbaric chamber pressurized to an equivalent of 42 m of sea water for 10 min. After one of the two dives, normobaric oxygen was breathed for 30 min, with air breathed after the other. Blood samples were obtained before and at 30–45 and 120 min after diving. Concentrations of glial fibrillary acidic, neurofilament light, and tau proteins were measured using single molecule array technology. Doppler ultrasound was used to detect venous gas emboli. RESULTS: Tau was significantly increased at 30–45 min after the second dive (p < 0.0098) and at 120 min after both dives (p < 0.0008/p < 0.0041). Comparison of matching samples showed that oxygen breathing after diving did not influence tau results. There was no correlation between tau concentrations and the presence of venous gas emboli. Glial fibrillary acidic protein was decreased 30–45 min after the first dive but at no other point. Neurofilament light concentrations did not change. CONCLUSIONS: Tau seems to be a promising marker of dive-related neuronal stress, which is independent of the presence of venous gas emboli. Future studies could validate these results and determine if there is a quantitative relationship between dive exposure and change in tau blood concentration. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00421-022-04892-9. Springer Berlin Heidelberg 2022-02-10 2022 /pmc/articles/PMC8926952/ /pubmed/35142945 http://dx.doi.org/10.1007/s00421-022-04892-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Rosén, Anders
Gennser, Mikael
Oscarsson, Nicklas
Kvarnström, Andreas
Sandström, Göran
Seeman-Lodding, Helen
Simrén, Joel
Zetterberg, Henrik
Protein tau concentration in blood increases after SCUBA diving: an observational study
title Protein tau concentration in blood increases after SCUBA diving: an observational study
title_full Protein tau concentration in blood increases after SCUBA diving: an observational study
title_fullStr Protein tau concentration in blood increases after SCUBA diving: an observational study
title_full_unstemmed Protein tau concentration in blood increases after SCUBA diving: an observational study
title_short Protein tau concentration in blood increases after SCUBA diving: an observational study
title_sort protein tau concentration in blood increases after scuba diving: an observational study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8926952/
https://www.ncbi.nlm.nih.gov/pubmed/35142945
http://dx.doi.org/10.1007/s00421-022-04892-9
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