Deficiency of Integrin β4 Results in Increased Lung Tissue Stiffness and Responds to Substrate Stiffness via Modulating RhoA Activity

The interaction between extracellular matrix (ECM) and epithelial cells plays a key role in lung development. Our studies found that mice with conditional integrin β4 (ITGB4) knockout presented lung dysplasia and increased stiffness of lung tissues. In accordance with our previous studies regarding...

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Detalles Bibliográficos
Autores principales: Chi, Yinxiu, Chen, Yu, Jiang, Wang, Huang, Wenjie, Ouyang, Mingxing, Liu, Lei, Pan, Yan, Li, Jingjing, Qu, Xiangping, Liu, Huijun, Liu, Chi, Deng, Linhong, Qin, Xiaoqun, Xiang, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8926985/
https://www.ncbi.nlm.nih.gov/pubmed/35309934
http://dx.doi.org/10.3389/fcell.2022.845440

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