Cargando…

Case Report: Appearance of Various Disease-Specific Antibodies After the Onset of Dipeptidyl Peptidase-4 Inhibitor-Associated Bullous Pemphigoid

Bullous pemphigoid (BP) is a rare autoimmune blistering disease, and the prevalence of type 2 diabetes mellitus (T2DM) is relatively high in subjects with BP. It is known that dipeptidyl peptidase-4 inhibitor (DPP-4i), one kind of antidiabetic drugs, can cause BP, although precise mechanism of DPP-4...

Descripción completa

Detalles Bibliográficos
Autores principales: Iwamoto, Yuichiro, Anno, Takatoshi, Koyama, Katsumasa, Kawasaki, Fumiko, Kaku, Kohei, Tomoda, Koichi, Sugiyama, Seiko, Aoyama, Yumi, Kaneto, Hideaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927025/
https://www.ncbi.nlm.nih.gov/pubmed/35309321
http://dx.doi.org/10.3389/fimmu.2022.843480
_version_ 1784670358688759808
author Iwamoto, Yuichiro
Anno, Takatoshi
Koyama, Katsumasa
Kawasaki, Fumiko
Kaku, Kohei
Tomoda, Koichi
Sugiyama, Seiko
Aoyama, Yumi
Kaneto, Hideaki
author_facet Iwamoto, Yuichiro
Anno, Takatoshi
Koyama, Katsumasa
Kawasaki, Fumiko
Kaku, Kohei
Tomoda, Koichi
Sugiyama, Seiko
Aoyama, Yumi
Kaneto, Hideaki
author_sort Iwamoto, Yuichiro
collection PubMed
description Bullous pemphigoid (BP) is a rare autoimmune blistering disease, and the prevalence of type 2 diabetes mellitus (T2DM) is relatively high in subjects with BP. It is known that dipeptidyl peptidase-4 inhibitor (DPP-4i), one kind of antidiabetic drugs, can cause BP, although precise mechanism of DPP-4i-related BP remains unclear. In this report, we showed a case with appearance of various disease-specific antibodies after the onset of DPP-4i-related BP. Furthermore, various disease-specific antibodies became positive and showed high titers two years after the onset of DPP-4i-related BP and discontinuation of DPP-4i. These data showed that it is possible for immune tolerance to be broken after the onset of DPP-4i-related BP, and it may be important to check autoimmune antibodies in DPP-4i-related BP subjects even when BP symptoms are improved.
format Online
Article
Text
id pubmed-8927025
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-89270252022-03-18 Case Report: Appearance of Various Disease-Specific Antibodies After the Onset of Dipeptidyl Peptidase-4 Inhibitor-Associated Bullous Pemphigoid Iwamoto, Yuichiro Anno, Takatoshi Koyama, Katsumasa Kawasaki, Fumiko Kaku, Kohei Tomoda, Koichi Sugiyama, Seiko Aoyama, Yumi Kaneto, Hideaki Front Immunol Immunology Bullous pemphigoid (BP) is a rare autoimmune blistering disease, and the prevalence of type 2 diabetes mellitus (T2DM) is relatively high in subjects with BP. It is known that dipeptidyl peptidase-4 inhibitor (DPP-4i), one kind of antidiabetic drugs, can cause BP, although precise mechanism of DPP-4i-related BP remains unclear. In this report, we showed a case with appearance of various disease-specific antibodies after the onset of DPP-4i-related BP. Furthermore, various disease-specific antibodies became positive and showed high titers two years after the onset of DPP-4i-related BP and discontinuation of DPP-4i. These data showed that it is possible for immune tolerance to be broken after the onset of DPP-4i-related BP, and it may be important to check autoimmune antibodies in DPP-4i-related BP subjects even when BP symptoms are improved. Frontiers Media S.A. 2022-03-03 /pmc/articles/PMC8927025/ /pubmed/35309321 http://dx.doi.org/10.3389/fimmu.2022.843480 Text en Copyright © 2022 Iwamoto, Anno, Koyama, Kawasaki, Kaku, Tomoda, Sugiyama, Aoyama and Kaneto https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Iwamoto, Yuichiro
Anno, Takatoshi
Koyama, Katsumasa
Kawasaki, Fumiko
Kaku, Kohei
Tomoda, Koichi
Sugiyama, Seiko
Aoyama, Yumi
Kaneto, Hideaki
Case Report: Appearance of Various Disease-Specific Antibodies After the Onset of Dipeptidyl Peptidase-4 Inhibitor-Associated Bullous Pemphigoid
title Case Report: Appearance of Various Disease-Specific Antibodies After the Onset of Dipeptidyl Peptidase-4 Inhibitor-Associated Bullous Pemphigoid
title_full Case Report: Appearance of Various Disease-Specific Antibodies After the Onset of Dipeptidyl Peptidase-4 Inhibitor-Associated Bullous Pemphigoid
title_fullStr Case Report: Appearance of Various Disease-Specific Antibodies After the Onset of Dipeptidyl Peptidase-4 Inhibitor-Associated Bullous Pemphigoid
title_full_unstemmed Case Report: Appearance of Various Disease-Specific Antibodies After the Onset of Dipeptidyl Peptidase-4 Inhibitor-Associated Bullous Pemphigoid
title_short Case Report: Appearance of Various Disease-Specific Antibodies After the Onset of Dipeptidyl Peptidase-4 Inhibitor-Associated Bullous Pemphigoid
title_sort case report: appearance of various disease-specific antibodies after the onset of dipeptidyl peptidase-4 inhibitor-associated bullous pemphigoid
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927025/
https://www.ncbi.nlm.nih.gov/pubmed/35309321
http://dx.doi.org/10.3389/fimmu.2022.843480
work_keys_str_mv AT iwamotoyuichiro casereportappearanceofvariousdiseasespecificantibodiesaftertheonsetofdipeptidylpeptidase4inhibitorassociatedbullouspemphigoid
AT annotakatoshi casereportappearanceofvariousdiseasespecificantibodiesaftertheonsetofdipeptidylpeptidase4inhibitorassociatedbullouspemphigoid
AT koyamakatsumasa casereportappearanceofvariousdiseasespecificantibodiesaftertheonsetofdipeptidylpeptidase4inhibitorassociatedbullouspemphigoid
AT kawasakifumiko casereportappearanceofvariousdiseasespecificantibodiesaftertheonsetofdipeptidylpeptidase4inhibitorassociatedbullouspemphigoid
AT kakukohei casereportappearanceofvariousdiseasespecificantibodiesaftertheonsetofdipeptidylpeptidase4inhibitorassociatedbullouspemphigoid
AT tomodakoichi casereportappearanceofvariousdiseasespecificantibodiesaftertheonsetofdipeptidylpeptidase4inhibitorassociatedbullouspemphigoid
AT sugiyamaseiko casereportappearanceofvariousdiseasespecificantibodiesaftertheonsetofdipeptidylpeptidase4inhibitorassociatedbullouspemphigoid
AT aoyamayumi casereportappearanceofvariousdiseasespecificantibodiesaftertheonsetofdipeptidylpeptidase4inhibitorassociatedbullouspemphigoid
AT kanetohideaki casereportappearanceofvariousdiseasespecificantibodiesaftertheonsetofdipeptidylpeptidase4inhibitorassociatedbullouspemphigoid