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Case Report: Appearance of Various Disease-Specific Antibodies After the Onset of Dipeptidyl Peptidase-4 Inhibitor-Associated Bullous Pemphigoid
Bullous pemphigoid (BP) is a rare autoimmune blistering disease, and the prevalence of type 2 diabetes mellitus (T2DM) is relatively high in subjects with BP. It is known that dipeptidyl peptidase-4 inhibitor (DPP-4i), one kind of antidiabetic drugs, can cause BP, although precise mechanism of DPP-4...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927025/ https://www.ncbi.nlm.nih.gov/pubmed/35309321 http://dx.doi.org/10.3389/fimmu.2022.843480 |
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author | Iwamoto, Yuichiro Anno, Takatoshi Koyama, Katsumasa Kawasaki, Fumiko Kaku, Kohei Tomoda, Koichi Sugiyama, Seiko Aoyama, Yumi Kaneto, Hideaki |
author_facet | Iwamoto, Yuichiro Anno, Takatoshi Koyama, Katsumasa Kawasaki, Fumiko Kaku, Kohei Tomoda, Koichi Sugiyama, Seiko Aoyama, Yumi Kaneto, Hideaki |
author_sort | Iwamoto, Yuichiro |
collection | PubMed |
description | Bullous pemphigoid (BP) is a rare autoimmune blistering disease, and the prevalence of type 2 diabetes mellitus (T2DM) is relatively high in subjects with BP. It is known that dipeptidyl peptidase-4 inhibitor (DPP-4i), one kind of antidiabetic drugs, can cause BP, although precise mechanism of DPP-4i-related BP remains unclear. In this report, we showed a case with appearance of various disease-specific antibodies after the onset of DPP-4i-related BP. Furthermore, various disease-specific antibodies became positive and showed high titers two years after the onset of DPP-4i-related BP and discontinuation of DPP-4i. These data showed that it is possible for immune tolerance to be broken after the onset of DPP-4i-related BP, and it may be important to check autoimmune antibodies in DPP-4i-related BP subjects even when BP symptoms are improved. |
format | Online Article Text |
id | pubmed-8927025 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89270252022-03-18 Case Report: Appearance of Various Disease-Specific Antibodies After the Onset of Dipeptidyl Peptidase-4 Inhibitor-Associated Bullous Pemphigoid Iwamoto, Yuichiro Anno, Takatoshi Koyama, Katsumasa Kawasaki, Fumiko Kaku, Kohei Tomoda, Koichi Sugiyama, Seiko Aoyama, Yumi Kaneto, Hideaki Front Immunol Immunology Bullous pemphigoid (BP) is a rare autoimmune blistering disease, and the prevalence of type 2 diabetes mellitus (T2DM) is relatively high in subjects with BP. It is known that dipeptidyl peptidase-4 inhibitor (DPP-4i), one kind of antidiabetic drugs, can cause BP, although precise mechanism of DPP-4i-related BP remains unclear. In this report, we showed a case with appearance of various disease-specific antibodies after the onset of DPP-4i-related BP. Furthermore, various disease-specific antibodies became positive and showed high titers two years after the onset of DPP-4i-related BP and discontinuation of DPP-4i. These data showed that it is possible for immune tolerance to be broken after the onset of DPP-4i-related BP, and it may be important to check autoimmune antibodies in DPP-4i-related BP subjects even when BP symptoms are improved. Frontiers Media S.A. 2022-03-03 /pmc/articles/PMC8927025/ /pubmed/35309321 http://dx.doi.org/10.3389/fimmu.2022.843480 Text en Copyright © 2022 Iwamoto, Anno, Koyama, Kawasaki, Kaku, Tomoda, Sugiyama, Aoyama and Kaneto https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Iwamoto, Yuichiro Anno, Takatoshi Koyama, Katsumasa Kawasaki, Fumiko Kaku, Kohei Tomoda, Koichi Sugiyama, Seiko Aoyama, Yumi Kaneto, Hideaki Case Report: Appearance of Various Disease-Specific Antibodies After the Onset of Dipeptidyl Peptidase-4 Inhibitor-Associated Bullous Pemphigoid |
title | Case Report: Appearance of Various Disease-Specific Antibodies After the Onset of Dipeptidyl Peptidase-4 Inhibitor-Associated Bullous Pemphigoid |
title_full | Case Report: Appearance of Various Disease-Specific Antibodies After the Onset of Dipeptidyl Peptidase-4 Inhibitor-Associated Bullous Pemphigoid |
title_fullStr | Case Report: Appearance of Various Disease-Specific Antibodies After the Onset of Dipeptidyl Peptidase-4 Inhibitor-Associated Bullous Pemphigoid |
title_full_unstemmed | Case Report: Appearance of Various Disease-Specific Antibodies After the Onset of Dipeptidyl Peptidase-4 Inhibitor-Associated Bullous Pemphigoid |
title_short | Case Report: Appearance of Various Disease-Specific Antibodies After the Onset of Dipeptidyl Peptidase-4 Inhibitor-Associated Bullous Pemphigoid |
title_sort | case report: appearance of various disease-specific antibodies after the onset of dipeptidyl peptidase-4 inhibitor-associated bullous pemphigoid |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927025/ https://www.ncbi.nlm.nih.gov/pubmed/35309321 http://dx.doi.org/10.3389/fimmu.2022.843480 |
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