The Role of Ferroptosis in the Treatment and Drug Resistance of Hepatocellular Carcinoma

Cell death is a fundamental feature of multicellular organisms’ development and a key driver of degenerative diseases. Ferroptosis is a new regulatory cell death mediated by iron-dependent lipid peroxidation, which is different from apoptosis and necrosis in morphology, pathophysiology and mechanism...

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Autores principales: Zhao, Siqi, Zheng, Wubin, Yu, Chao, Xu, Gaoxin, Zhang, Xinyi, Pan, Chao, Feng, Yongheng, Yang, Kunxing, Zhou, Jin, Ma, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927068/
https://www.ncbi.nlm.nih.gov/pubmed/35309918
http://dx.doi.org/10.3389/fcell.2022.845232
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author Zhao, Siqi
Zheng, Wubin
Yu, Chao
Xu, Gaoxin
Zhang, Xinyi
Pan, Chao
Feng, Yongheng
Yang, Kunxing
Zhou, Jin
Ma, Yong
author_facet Zhao, Siqi
Zheng, Wubin
Yu, Chao
Xu, Gaoxin
Zhang, Xinyi
Pan, Chao
Feng, Yongheng
Yang, Kunxing
Zhou, Jin
Ma, Yong
author_sort Zhao, Siqi
collection PubMed
description Cell death is a fundamental feature of multicellular organisms’ development and a key driver of degenerative diseases. Ferroptosis is a new regulatory cell death mediated by iron-dependent lipid peroxidation, which is different from apoptosis and necrosis in morphology, pathophysiology and mechanism. Recent studies have found that ferroptosis is involved in the development of many diseases including hepatocellular carcinoma (HCC). As further research progresses, specific mechanisms of ferroptosis in HCC are being revealed. In this review, we summarize these recent advances about the treatment of drug-resistance in HCC and the latest ferroptosis-related treatment for HCC.
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spelling pubmed-89270682022-03-18 The Role of Ferroptosis in the Treatment and Drug Resistance of Hepatocellular Carcinoma Zhao, Siqi Zheng, Wubin Yu, Chao Xu, Gaoxin Zhang, Xinyi Pan, Chao Feng, Yongheng Yang, Kunxing Zhou, Jin Ma, Yong Front Cell Dev Biol Cell and Developmental Biology Cell death is a fundamental feature of multicellular organisms’ development and a key driver of degenerative diseases. Ferroptosis is a new regulatory cell death mediated by iron-dependent lipid peroxidation, which is different from apoptosis and necrosis in morphology, pathophysiology and mechanism. Recent studies have found that ferroptosis is involved in the development of many diseases including hepatocellular carcinoma (HCC). As further research progresses, specific mechanisms of ferroptosis in HCC are being revealed. In this review, we summarize these recent advances about the treatment of drug-resistance in HCC and the latest ferroptosis-related treatment for HCC. Frontiers Media S.A. 2022-03-03 /pmc/articles/PMC8927068/ /pubmed/35309918 http://dx.doi.org/10.3389/fcell.2022.845232 Text en Copyright © 2022 Zhao, Zheng, Yu, Xu, Zhang, Pan, Feng, Yang, Zhou and Ma. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Zhao, Siqi
Zheng, Wubin
Yu, Chao
Xu, Gaoxin
Zhang, Xinyi
Pan, Chao
Feng, Yongheng
Yang, Kunxing
Zhou, Jin
Ma, Yong
The Role of Ferroptosis in the Treatment and Drug Resistance of Hepatocellular Carcinoma
title The Role of Ferroptosis in the Treatment and Drug Resistance of Hepatocellular Carcinoma
title_full The Role of Ferroptosis in the Treatment and Drug Resistance of Hepatocellular Carcinoma
title_fullStr The Role of Ferroptosis in the Treatment and Drug Resistance of Hepatocellular Carcinoma
title_full_unstemmed The Role of Ferroptosis in the Treatment and Drug Resistance of Hepatocellular Carcinoma
title_short The Role of Ferroptosis in the Treatment and Drug Resistance of Hepatocellular Carcinoma
title_sort role of ferroptosis in the treatment and drug resistance of hepatocellular carcinoma
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927068/
https://www.ncbi.nlm.nih.gov/pubmed/35309918
http://dx.doi.org/10.3389/fcell.2022.845232
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