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Clinical characteristics and pachychoroid incidence in Japanese patients with neovascular age-related macular degeneration

The phenotypes of neovascular age-related macular degeneration (nAMD) are recognized as differing between Caucasian and Asian patients. Pachychoroid is thought to be more prevalent in Asians than in Caucasians, and may be involved in the development of nAMD in Asian patients. Therefore, we investiga...

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Autores principales: Matsumoto, Hidetaka, Hoshino, Junki, Mukai, Ryo, Nakamura, Kosuke, Kishi, Shoji, Akiyama, Hideo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927155/
https://www.ncbi.nlm.nih.gov/pubmed/35296769
http://dx.doi.org/10.1038/s41598-022-08666-3
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author Matsumoto, Hidetaka
Hoshino, Junki
Mukai, Ryo
Nakamura, Kosuke
Kishi, Shoji
Akiyama, Hideo
author_facet Matsumoto, Hidetaka
Hoshino, Junki
Mukai, Ryo
Nakamura, Kosuke
Kishi, Shoji
Akiyama, Hideo
author_sort Matsumoto, Hidetaka
collection PubMed
description The phenotypes of neovascular age-related macular degeneration (nAMD) are recognized as differing between Caucasian and Asian patients. Pachychoroid is thought to be more prevalent in Asians than in Caucasians, and may be involved in the development of nAMD in Asian patients. Therefore, we investigated the clinical characteristics and pachychoroid incidence in Japanese patients with nAMD. We retrospectively analyzed 385 eyes of 370 consecutive Japanese patients with treatment naïve nAMD. According to the nAMD nomenclature, type 1 macular neovascularization (MNV) was observed in 132 eyes (34.3%), polypoidal choroidal vasculopathy (PCV) in 137 (35.6%), mixed type 1 and type 2 MNV in 32 (8.3%), type 2 MNV in 43 (11.2%), and type 3 MNV in 41 (10.6%). Pachychoroid was seen in 58.3% of type 1 MNV, 75.2% of PCV, 34.4% of mixed type 1 and type 2 MNV, 14.0% of type 2 MNV, and 0% of type 3 MNV. Compared to nAMD patients without pachychoroid (188 eyes), those who had nAMD with pachychoroid (197 eyes) were significantly younger, had a higher proportion of males, greater central choroidal thickness, and a higher frequency of macular vortex vein anastomoses (all P < 0.001). Furthermore, drusen subtypes differed significantly between the two groups (P < 0.001). These results suggest that most Japanese nAMD patients might have type 1 MNV or PCV. Moreover, in approximately half of patients, nAMD might be associated with pachychoroid, and choroidal congestion may be involved in the development of MNV in these cases.
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spelling pubmed-89271552022-03-17 Clinical characteristics and pachychoroid incidence in Japanese patients with neovascular age-related macular degeneration Matsumoto, Hidetaka Hoshino, Junki Mukai, Ryo Nakamura, Kosuke Kishi, Shoji Akiyama, Hideo Sci Rep Article The phenotypes of neovascular age-related macular degeneration (nAMD) are recognized as differing between Caucasian and Asian patients. Pachychoroid is thought to be more prevalent in Asians than in Caucasians, and may be involved in the development of nAMD in Asian patients. Therefore, we investigated the clinical characteristics and pachychoroid incidence in Japanese patients with nAMD. We retrospectively analyzed 385 eyes of 370 consecutive Japanese patients with treatment naïve nAMD. According to the nAMD nomenclature, type 1 macular neovascularization (MNV) was observed in 132 eyes (34.3%), polypoidal choroidal vasculopathy (PCV) in 137 (35.6%), mixed type 1 and type 2 MNV in 32 (8.3%), type 2 MNV in 43 (11.2%), and type 3 MNV in 41 (10.6%). Pachychoroid was seen in 58.3% of type 1 MNV, 75.2% of PCV, 34.4% of mixed type 1 and type 2 MNV, 14.0% of type 2 MNV, and 0% of type 3 MNV. Compared to nAMD patients without pachychoroid (188 eyes), those who had nAMD with pachychoroid (197 eyes) were significantly younger, had a higher proportion of males, greater central choroidal thickness, and a higher frequency of macular vortex vein anastomoses (all P < 0.001). Furthermore, drusen subtypes differed significantly between the two groups (P < 0.001). These results suggest that most Japanese nAMD patients might have type 1 MNV or PCV. Moreover, in approximately half of patients, nAMD might be associated with pachychoroid, and choroidal congestion may be involved in the development of MNV in these cases. Nature Publishing Group UK 2022-03-16 /pmc/articles/PMC8927155/ /pubmed/35296769 http://dx.doi.org/10.1038/s41598-022-08666-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Matsumoto, Hidetaka
Hoshino, Junki
Mukai, Ryo
Nakamura, Kosuke
Kishi, Shoji
Akiyama, Hideo
Clinical characteristics and pachychoroid incidence in Japanese patients with neovascular age-related macular degeneration
title Clinical characteristics and pachychoroid incidence in Japanese patients with neovascular age-related macular degeneration
title_full Clinical characteristics and pachychoroid incidence in Japanese patients with neovascular age-related macular degeneration
title_fullStr Clinical characteristics and pachychoroid incidence in Japanese patients with neovascular age-related macular degeneration
title_full_unstemmed Clinical characteristics and pachychoroid incidence in Japanese patients with neovascular age-related macular degeneration
title_short Clinical characteristics and pachychoroid incidence in Japanese patients with neovascular age-related macular degeneration
title_sort clinical characteristics and pachychoroid incidence in japanese patients with neovascular age-related macular degeneration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927155/
https://www.ncbi.nlm.nih.gov/pubmed/35296769
http://dx.doi.org/10.1038/s41598-022-08666-3
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