The aberrant upregulation of exon 10-inclusive SREK1 through SRSF10 acts as an oncogenic driver in human hepatocellular carcinoma

Deregulation of alternative splicing is implicated as a relevant source of molecular heterogeneity in cancer. However, the targets and intrinsic mechanisms of splicing in hepatocarcinogenesis are largely unknown. Here, we report a functional impact of a Splicing Regulatory Glutamine/Lysine-Rich Prot...

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Detalles Bibliográficos
Autores principales: Chang, Cunjie, Rajasekaran, Muthukumar, Qiao, Yiting, Dong, Heng, Wang, Yu, Xia, Hongping, Deivasigamani, Amudha, Wu, Minjie, Sekar, Karthik, Gao, Hengjun, Sun, Mengqing, Niu, Yuqin, Li, Qian, Tao, Lin, Yan, Zhen, Wang, Menglan, Chen, Shasha, Zhao, Shujuan, Chen, Dajing, Li, Lina, Yang, Fan, Gao, Haojin, Chen, Baodong, Su, Ling, Xu, Liang, Chen, Ye, Seshachalam, Veerabrahma Pratap, Chen, Gongxing, Gunaratne, Jayantha, Hong, Wanjin, Shi, Junping, Chen, Gongying, Grierson, David S., Chabot, Benoit, Xie, Tian, Hui, Kam Man, Chen, Jianxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927159/
https://www.ncbi.nlm.nih.gov/pubmed/35296659
http://dx.doi.org/10.1038/s41467-022-29016-x

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