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Electrodermal Activity Biofeedback Alters Evolving Functional Brain Networks in People With Epilepsy, but in a Non-specific Manner

There is evidence that biofeedback of electrodermal activity (EDA) can reduce seizure frequency in people with epilepsy. Prior studies have linked EDA biofeedback to a diffuse brain activation as a potential functional mechanism. Here, we investigated whether short-term EDA biofeedback alters EEG-de...

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Autores principales: Schach, Sophia, Rings, Thorsten, Bregulla, Madeleine, Witt, Juri-Alexander, Bröhl, Timo, Surges, Rainer, von Wrede, Randi, Lehnertz, Klaus, Helmstaedter, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927283/
https://www.ncbi.nlm.nih.gov/pubmed/35310086
http://dx.doi.org/10.3389/fnins.2022.828283
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author Schach, Sophia
Rings, Thorsten
Bregulla, Madeleine
Witt, Juri-Alexander
Bröhl, Timo
Surges, Rainer
von Wrede, Randi
Lehnertz, Klaus
Helmstaedter, Christoph
author_facet Schach, Sophia
Rings, Thorsten
Bregulla, Madeleine
Witt, Juri-Alexander
Bröhl, Timo
Surges, Rainer
von Wrede, Randi
Lehnertz, Klaus
Helmstaedter, Christoph
author_sort Schach, Sophia
collection PubMed
description There is evidence that biofeedback of electrodermal activity (EDA) can reduce seizure frequency in people with epilepsy. Prior studies have linked EDA biofeedback to a diffuse brain activation as a potential functional mechanism. Here, we investigated whether short-term EDA biofeedback alters EEG-derived large-scale functional brain networks in people with epilepsy. In this prospective controlled trial, thirty participants were quasi-randomly assigned to one of three biofeedback conditions (arousal, sham, or relaxation) and performed a single, 30-min biofeedback training while undergoing continuous EEG recordings. Based on the EEG, we derived evolving functional brain networks and examined their topological, robustness, and stability properties over time. Potential effects on attentional-executive functions and mood were monitored via a neuropsychological assessment and subjective self-ratings. Participants assigned to the relaxation group seemed to be most successful in meeting the task requirements for this specific control condition (i.e., decreasing EDA). Participants in the sham group were more successful in increasing EDA than participants in the arousal group. However, only the arousal biofeedback training was associated with a prolonged robustness-enhancing effect on networks. Effects on other network properties were mostly unspecific for the different groups. None of the biofeedback conditions affected attentional-executive functions or subjective behavioral measures. Our results suggest that global characteristics of evolving functional brain networks are modified by EDA biofeedback. Some alterations persisted after the single training session; however, the effects were largely unspecific across the different biofeedback protocols. Further research should address changes of local network characteristics and whether multiple training sessions will result in more specific network modifications.
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spelling pubmed-89272832022-03-18 Electrodermal Activity Biofeedback Alters Evolving Functional Brain Networks in People With Epilepsy, but in a Non-specific Manner Schach, Sophia Rings, Thorsten Bregulla, Madeleine Witt, Juri-Alexander Bröhl, Timo Surges, Rainer von Wrede, Randi Lehnertz, Klaus Helmstaedter, Christoph Front Neurosci Neuroscience There is evidence that biofeedback of electrodermal activity (EDA) can reduce seizure frequency in people with epilepsy. Prior studies have linked EDA biofeedback to a diffuse brain activation as a potential functional mechanism. Here, we investigated whether short-term EDA biofeedback alters EEG-derived large-scale functional brain networks in people with epilepsy. In this prospective controlled trial, thirty participants were quasi-randomly assigned to one of three biofeedback conditions (arousal, sham, or relaxation) and performed a single, 30-min biofeedback training while undergoing continuous EEG recordings. Based on the EEG, we derived evolving functional brain networks and examined their topological, robustness, and stability properties over time. Potential effects on attentional-executive functions and mood were monitored via a neuropsychological assessment and subjective self-ratings. Participants assigned to the relaxation group seemed to be most successful in meeting the task requirements for this specific control condition (i.e., decreasing EDA). Participants in the sham group were more successful in increasing EDA than participants in the arousal group. However, only the arousal biofeedback training was associated with a prolonged robustness-enhancing effect on networks. Effects on other network properties were mostly unspecific for the different groups. None of the biofeedback conditions affected attentional-executive functions or subjective behavioral measures. Our results suggest that global characteristics of evolving functional brain networks are modified by EDA biofeedback. Some alterations persisted after the single training session; however, the effects were largely unspecific across the different biofeedback protocols. Further research should address changes of local network characteristics and whether multiple training sessions will result in more specific network modifications. Frontiers Media S.A. 2022-03-03 /pmc/articles/PMC8927283/ /pubmed/35310086 http://dx.doi.org/10.3389/fnins.2022.828283 Text en Copyright © 2022 Schach, Rings, Bregulla, Witt, Bröhl, Surges, von Wrede, Lehnertz and Helmstaedter. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Schach, Sophia
Rings, Thorsten
Bregulla, Madeleine
Witt, Juri-Alexander
Bröhl, Timo
Surges, Rainer
von Wrede, Randi
Lehnertz, Klaus
Helmstaedter, Christoph
Electrodermal Activity Biofeedback Alters Evolving Functional Brain Networks in People With Epilepsy, but in a Non-specific Manner
title Electrodermal Activity Biofeedback Alters Evolving Functional Brain Networks in People With Epilepsy, but in a Non-specific Manner
title_full Electrodermal Activity Biofeedback Alters Evolving Functional Brain Networks in People With Epilepsy, but in a Non-specific Manner
title_fullStr Electrodermal Activity Biofeedback Alters Evolving Functional Brain Networks in People With Epilepsy, but in a Non-specific Manner
title_full_unstemmed Electrodermal Activity Biofeedback Alters Evolving Functional Brain Networks in People With Epilepsy, but in a Non-specific Manner
title_short Electrodermal Activity Biofeedback Alters Evolving Functional Brain Networks in People With Epilepsy, but in a Non-specific Manner
title_sort electrodermal activity biofeedback alters evolving functional brain networks in people with epilepsy, but in a non-specific manner
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927283/
https://www.ncbi.nlm.nih.gov/pubmed/35310086
http://dx.doi.org/10.3389/fnins.2022.828283
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