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Versatile subtypes of pericytes and their roles in spinal cord injury repair, bone development and repair

Vascular regeneration is a challenging topic in tissue repair. As one of the important components of the neurovascular unit (NVU), pericytes play an essential role in the maintenance of the vascular network of the spinal cord. To date, subtypes of pericytes have been identified by various markers, n...

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Autores principales: Zhu, Sipin, Chen, Min, Ying, Yibo, Wu, Qiuji, Huang, Zhiyang, Ni, Wenfei, Wang, Xiangyang, Xu, Huazi, Bennett, Samuel, Xiao, Jian, Xu, Jiake
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927336/
https://www.ncbi.nlm.nih.gov/pubmed/35296645
http://dx.doi.org/10.1038/s41413-022-00203-2
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author Zhu, Sipin
Chen, Min
Ying, Yibo
Wu, Qiuji
Huang, Zhiyang
Ni, Wenfei
Wang, Xiangyang
Xu, Huazi
Bennett, Samuel
Xiao, Jian
Xu, Jiake
author_facet Zhu, Sipin
Chen, Min
Ying, Yibo
Wu, Qiuji
Huang, Zhiyang
Ni, Wenfei
Wang, Xiangyang
Xu, Huazi
Bennett, Samuel
Xiao, Jian
Xu, Jiake
author_sort Zhu, Sipin
collection PubMed
description Vascular regeneration is a challenging topic in tissue repair. As one of the important components of the neurovascular unit (NVU), pericytes play an essential role in the maintenance of the vascular network of the spinal cord. To date, subtypes of pericytes have been identified by various markers, namely the PDGFR-β, Desmin, CD146, and NG2, each of which is involved with spinal cord injury (SCI) repair. In addition, pericytes may act as a stem cell source that is important for bone development and regeneration, whilst specific subtypes of pericyte could facilitate bone fracture and defect repair. One of the major challenges of pericyte biology is to determine the specific markers that would clearly distinguish the different subtypes of pericytes, and to develop efficient approaches to isolate and propagate pericytes. In this review, we discuss the biology and roles of pericytes, their markers for identification, and cell differentiation capacity with a focus on the potential application in the treatment of SCI and bone diseases in orthopedics.
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spelling pubmed-89273362022-04-01 Versatile subtypes of pericytes and their roles in spinal cord injury repair, bone development and repair Zhu, Sipin Chen, Min Ying, Yibo Wu, Qiuji Huang, Zhiyang Ni, Wenfei Wang, Xiangyang Xu, Huazi Bennett, Samuel Xiao, Jian Xu, Jiake Bone Res Review Article Vascular regeneration is a challenging topic in tissue repair. As one of the important components of the neurovascular unit (NVU), pericytes play an essential role in the maintenance of the vascular network of the spinal cord. To date, subtypes of pericytes have been identified by various markers, namely the PDGFR-β, Desmin, CD146, and NG2, each of which is involved with spinal cord injury (SCI) repair. In addition, pericytes may act as a stem cell source that is important for bone development and regeneration, whilst specific subtypes of pericyte could facilitate bone fracture and defect repair. One of the major challenges of pericyte biology is to determine the specific markers that would clearly distinguish the different subtypes of pericytes, and to develop efficient approaches to isolate and propagate pericytes. In this review, we discuss the biology and roles of pericytes, their markers for identification, and cell differentiation capacity with a focus on the potential application in the treatment of SCI and bone diseases in orthopedics. Nature Publishing Group UK 2022-03-16 /pmc/articles/PMC8927336/ /pubmed/35296645 http://dx.doi.org/10.1038/s41413-022-00203-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Zhu, Sipin
Chen, Min
Ying, Yibo
Wu, Qiuji
Huang, Zhiyang
Ni, Wenfei
Wang, Xiangyang
Xu, Huazi
Bennett, Samuel
Xiao, Jian
Xu, Jiake
Versatile subtypes of pericytes and their roles in spinal cord injury repair, bone development and repair
title Versatile subtypes of pericytes and their roles in spinal cord injury repair, bone development and repair
title_full Versatile subtypes of pericytes and their roles in spinal cord injury repair, bone development and repair
title_fullStr Versatile subtypes of pericytes and their roles in spinal cord injury repair, bone development and repair
title_full_unstemmed Versatile subtypes of pericytes and their roles in spinal cord injury repair, bone development and repair
title_short Versatile subtypes of pericytes and their roles in spinal cord injury repair, bone development and repair
title_sort versatile subtypes of pericytes and their roles in spinal cord injury repair, bone development and repair
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927336/
https://www.ncbi.nlm.nih.gov/pubmed/35296645
http://dx.doi.org/10.1038/s41413-022-00203-2
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