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Reduced cerebellar cortical thickness in World Trade Center responders with cognitive impairment
Prior research has demonstrated high levels of cognitive and physical functional impairments in World Trade Center (WTC) responders. A follow-up neuroimaging study identified changes to white matter connectivity within the cerebellum in responders with cognitive impairment (CI). In the first study t...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927406/ https://www.ncbi.nlm.nih.gov/pubmed/35296637 http://dx.doi.org/10.1038/s41398-022-01873-6 |
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author | Clouston, Sean A. P. Kritikos, Minos Huang, Chuan Kuan, Pei-Fen Vaska, Paul Pellecchia, Alison C. Santiago-Michels, Stephanie Carr, Melissa A. Gandy, Sam Sano, Mary Bromet, Evelyn J. Lucchini, Roberto G. Luft, Benjamin J. |
author_facet | Clouston, Sean A. P. Kritikos, Minos Huang, Chuan Kuan, Pei-Fen Vaska, Paul Pellecchia, Alison C. Santiago-Michels, Stephanie Carr, Melissa A. Gandy, Sam Sano, Mary Bromet, Evelyn J. Lucchini, Roberto G. Luft, Benjamin J. |
author_sort | Clouston, Sean A. P. |
collection | PubMed |
description | Prior research has demonstrated high levels of cognitive and physical functional impairments in World Trade Center (WTC) responders. A follow-up neuroimaging study identified changes to white matter connectivity within the cerebellum in responders with cognitive impairment (CI). In the first study to examine cerebellar cortical thickness in WTC responders with CI, we fielded a structural magnetic resonance imaging protocol. WTC responders (N = 99) participated in a structural magnetic resonance imaging (MRI) study, of whom 48 had CI. Participants with CI did not differ demographically or by intracranial volume when compared to cognitively unimpaired participants. MRIs were processed using the CERES imaging pipeline; bilateral cortical thickness in 12 cerebellar lobules was reported. Analyses were completed comparing mean cerebellar cortical thickness across groups. Lobules were examined to determine the location and functional correlates of reduced cerebellar cortical thickness. Multivariable-adjusted analyses accounted for the false discovery rate. Mean cerebellar cortical thickness was reduced by 0.17 mm in responders with CI. Decrements in cerebellar cortical thickness were symmetric and located in the Cerebellar Crus (I and II), and in Lobules IV, VI, VIIb, VIIIa, VIIIb, and IX. Cerebellar cortical thickness was associated with episodic memory, response speed, and tandem balance. WTC responders with CI had evidence of reduced cerebellar cortical thickness that was present across lobules in a pattern unique to this cohort. |
format | Online Article Text |
id | pubmed-8927406 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-89274062022-04-01 Reduced cerebellar cortical thickness in World Trade Center responders with cognitive impairment Clouston, Sean A. P. Kritikos, Minos Huang, Chuan Kuan, Pei-Fen Vaska, Paul Pellecchia, Alison C. Santiago-Michels, Stephanie Carr, Melissa A. Gandy, Sam Sano, Mary Bromet, Evelyn J. Lucchini, Roberto G. Luft, Benjamin J. Transl Psychiatry Article Prior research has demonstrated high levels of cognitive and physical functional impairments in World Trade Center (WTC) responders. A follow-up neuroimaging study identified changes to white matter connectivity within the cerebellum in responders with cognitive impairment (CI). In the first study to examine cerebellar cortical thickness in WTC responders with CI, we fielded a structural magnetic resonance imaging protocol. WTC responders (N = 99) participated in a structural magnetic resonance imaging (MRI) study, of whom 48 had CI. Participants with CI did not differ demographically or by intracranial volume when compared to cognitively unimpaired participants. MRIs were processed using the CERES imaging pipeline; bilateral cortical thickness in 12 cerebellar lobules was reported. Analyses were completed comparing mean cerebellar cortical thickness across groups. Lobules were examined to determine the location and functional correlates of reduced cerebellar cortical thickness. Multivariable-adjusted analyses accounted for the false discovery rate. Mean cerebellar cortical thickness was reduced by 0.17 mm in responders with CI. Decrements in cerebellar cortical thickness were symmetric and located in the Cerebellar Crus (I and II), and in Lobules IV, VI, VIIb, VIIIa, VIIIb, and IX. Cerebellar cortical thickness was associated with episodic memory, response speed, and tandem balance. WTC responders with CI had evidence of reduced cerebellar cortical thickness that was present across lobules in a pattern unique to this cohort. Nature Publishing Group UK 2022-03-16 /pmc/articles/PMC8927406/ /pubmed/35296637 http://dx.doi.org/10.1038/s41398-022-01873-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Clouston, Sean A. P. Kritikos, Minos Huang, Chuan Kuan, Pei-Fen Vaska, Paul Pellecchia, Alison C. Santiago-Michels, Stephanie Carr, Melissa A. Gandy, Sam Sano, Mary Bromet, Evelyn J. Lucchini, Roberto G. Luft, Benjamin J. Reduced cerebellar cortical thickness in World Trade Center responders with cognitive impairment |
title | Reduced cerebellar cortical thickness in World Trade Center responders with cognitive impairment |
title_full | Reduced cerebellar cortical thickness in World Trade Center responders with cognitive impairment |
title_fullStr | Reduced cerebellar cortical thickness in World Trade Center responders with cognitive impairment |
title_full_unstemmed | Reduced cerebellar cortical thickness in World Trade Center responders with cognitive impairment |
title_short | Reduced cerebellar cortical thickness in World Trade Center responders with cognitive impairment |
title_sort | reduced cerebellar cortical thickness in world trade center responders with cognitive impairment |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927406/ https://www.ncbi.nlm.nih.gov/pubmed/35296637 http://dx.doi.org/10.1038/s41398-022-01873-6 |
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