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Regulation of the Tec family of non-receptor tyrosine kinases in cardiovascular disease

Tyrosine phosphorylation by protein tyrosine kinases (PTKs) is a type of post-translational modification. Tec kinases, which are a subfamily of non-receptor PTKs, were originally discovered in the hematopoietic system and include five members: Tec, Btk, Itk/Emt/Tsk, Etk/Bmx, and Txk/Rlk. With the pr...

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Autores principales: Yin, Zeyu, Zou, Yuanming, Wang, Dong, Huang, Xinyue, Xiong, Shengjun, Cao, Liu, Zhang, Ying, Sun, Yingxian, Zhang, Naijin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927484/
https://www.ncbi.nlm.nih.gov/pubmed/35296647
http://dx.doi.org/10.1038/s41420-022-00927-4
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author Yin, Zeyu
Zou, Yuanming
Wang, Dong
Huang, Xinyue
Xiong, Shengjun
Cao, Liu
Zhang, Ying
Sun, Yingxian
Zhang, Naijin
author_facet Yin, Zeyu
Zou, Yuanming
Wang, Dong
Huang, Xinyue
Xiong, Shengjun
Cao, Liu
Zhang, Ying
Sun, Yingxian
Zhang, Naijin
author_sort Yin, Zeyu
collection PubMed
description Tyrosine phosphorylation by protein tyrosine kinases (PTKs) is a type of post-translational modification. Tec kinases, which are a subfamily of non-receptor PTKs, were originally discovered in the hematopoietic system and include five members: Tec, Btk, Itk/Emt/Tsk, Etk/Bmx, and Txk/Rlk. With the progression of modern research, certain members of the Tec family of kinases have been found to be expressed outside the hematopoietic system and are involved in the development and progression of a variety of diseases. The role of Tec family kinases in cardiovascular disease is receiving increasing attention. Tec kinases are involved in the occurrence and progression of ischemic heart disease, atherosclerosis, cardiac dysfunction associated with sepsis, atrial fibrillation, myocardial hypertrophy, coronary atherosclerotic heart disease, and myocardial infarction and post-myocardial. However, no reviews have comprehensively clarified the role of Tec kinases in the cardiovascular system. Therefore, this review summarizes research on the role of Tec kinases in cardiovascular disease, providing new insights into the prevention and treatment of cardiovascular disease.
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spelling pubmed-89274842022-04-01 Regulation of the Tec family of non-receptor tyrosine kinases in cardiovascular disease Yin, Zeyu Zou, Yuanming Wang, Dong Huang, Xinyue Xiong, Shengjun Cao, Liu Zhang, Ying Sun, Yingxian Zhang, Naijin Cell Death Discov Review Article Tyrosine phosphorylation by protein tyrosine kinases (PTKs) is a type of post-translational modification. Tec kinases, which are a subfamily of non-receptor PTKs, were originally discovered in the hematopoietic system and include five members: Tec, Btk, Itk/Emt/Tsk, Etk/Bmx, and Txk/Rlk. With the progression of modern research, certain members of the Tec family of kinases have been found to be expressed outside the hematopoietic system and are involved in the development and progression of a variety of diseases. The role of Tec family kinases in cardiovascular disease is receiving increasing attention. Tec kinases are involved in the occurrence and progression of ischemic heart disease, atherosclerosis, cardiac dysfunction associated with sepsis, atrial fibrillation, myocardial hypertrophy, coronary atherosclerotic heart disease, and myocardial infarction and post-myocardial. However, no reviews have comprehensively clarified the role of Tec kinases in the cardiovascular system. Therefore, this review summarizes research on the role of Tec kinases in cardiovascular disease, providing new insights into the prevention and treatment of cardiovascular disease. Nature Publishing Group UK 2022-03-16 /pmc/articles/PMC8927484/ /pubmed/35296647 http://dx.doi.org/10.1038/s41420-022-00927-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Yin, Zeyu
Zou, Yuanming
Wang, Dong
Huang, Xinyue
Xiong, Shengjun
Cao, Liu
Zhang, Ying
Sun, Yingxian
Zhang, Naijin
Regulation of the Tec family of non-receptor tyrosine kinases in cardiovascular disease
title Regulation of the Tec family of non-receptor tyrosine kinases in cardiovascular disease
title_full Regulation of the Tec family of non-receptor tyrosine kinases in cardiovascular disease
title_fullStr Regulation of the Tec family of non-receptor tyrosine kinases in cardiovascular disease
title_full_unstemmed Regulation of the Tec family of non-receptor tyrosine kinases in cardiovascular disease
title_short Regulation of the Tec family of non-receptor tyrosine kinases in cardiovascular disease
title_sort regulation of the tec family of non-receptor tyrosine kinases in cardiovascular disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927484/
https://www.ncbi.nlm.nih.gov/pubmed/35296647
http://dx.doi.org/10.1038/s41420-022-00927-4
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