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Elevation Matrix Data in the Evaluation of Keratoconus and Normal Corneas

INTRODUCTION: To determine whether elevation matrix data of the anterior corneal surface could be useful for the diagnosis of keratoconus. METHODS: In a cross-sectional study, subjects aged 10–40 years with keratoconus (n = 74) or age-matched controls (n = 36) underwent complete ophthalmological exa...

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Autores principales: Tejedor, Jaime, Gutiérrez-Carmona, Francisco J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927558/
https://www.ncbi.nlm.nih.gov/pubmed/35032006
http://dx.doi.org/10.1007/s40123-022-00454-6
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author Tejedor, Jaime
Gutiérrez-Carmona, Francisco J.
author_facet Tejedor, Jaime
Gutiérrez-Carmona, Francisco J.
author_sort Tejedor, Jaime
collection PubMed
description INTRODUCTION: To determine whether elevation matrix data of the anterior corneal surface could be useful for the diagnosis of keratoconus. METHODS: In a cross-sectional study, subjects aged 10–40 years with keratoconus (n = 74) or age-matched controls (n = 36) underwent complete ophthalmological examination, including Scheimpflug corneal topography (Pentacam HR). Exclusion criteria comprised previous ocular surgery, other eye disease, or significant corneal scarring. A raw data matrix of distance measurements to the most anterior corneal point was used to compare each subject with the mean normal cornea. A central 6-mm zone (6.1 × 6.1 mm) and two inferior eccentric matrices (0.4 × 6.1 and 1.1 × 1.1 mm) were used. Outcome measures were sensitivity, specificity, positive and negative predictive value, likelihood ratio, accuracy, and odds ratio. RESULTS: Sensitivity of central matrix for the diagnosis of keratoconus was low (6.7%) whereas specificity reached 94.4%. Sensitivity and specificity were respectively 93.2% and 94% for the 6.1 × 0.4 mm eccentric matrix and 97.2% and 97.2% for the 1.1 × 1.1 mm eccentric matrix. Positive predictive and negative predictive values were 71.4% and 33%, respectively, for the central matrix; 97.1% and 87.1%; 98.6% and 94.5%, for the two eccentric matrices, respectively. The likelihood ratio of a positive test was 1.1, 16.7, and 35, respectively. Sensitivity and specificity of the eccentric matrices were significantly better in the diagnosis of subclinical keratoconus (but not definite keratoconus) than other Pentacam indices. CONCLUSIONS: Using eccentric elevation matrix data analysis of the cornea is useful in the detection of keratoconus versus normal corneas. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40123-022-00454-6.
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spelling pubmed-89275582022-04-01 Elevation Matrix Data in the Evaluation of Keratoconus and Normal Corneas Tejedor, Jaime Gutiérrez-Carmona, Francisco J. Ophthalmol Ther Original Research INTRODUCTION: To determine whether elevation matrix data of the anterior corneal surface could be useful for the diagnosis of keratoconus. METHODS: In a cross-sectional study, subjects aged 10–40 years with keratoconus (n = 74) or age-matched controls (n = 36) underwent complete ophthalmological examination, including Scheimpflug corneal topography (Pentacam HR). Exclusion criteria comprised previous ocular surgery, other eye disease, or significant corneal scarring. A raw data matrix of distance measurements to the most anterior corneal point was used to compare each subject with the mean normal cornea. A central 6-mm zone (6.1 × 6.1 mm) and two inferior eccentric matrices (0.4 × 6.1 and 1.1 × 1.1 mm) were used. Outcome measures were sensitivity, specificity, positive and negative predictive value, likelihood ratio, accuracy, and odds ratio. RESULTS: Sensitivity of central matrix for the diagnosis of keratoconus was low (6.7%) whereas specificity reached 94.4%. Sensitivity and specificity were respectively 93.2% and 94% for the 6.1 × 0.4 mm eccentric matrix and 97.2% and 97.2% for the 1.1 × 1.1 mm eccentric matrix. Positive predictive and negative predictive values were 71.4% and 33%, respectively, for the central matrix; 97.1% and 87.1%; 98.6% and 94.5%, for the two eccentric matrices, respectively. The likelihood ratio of a positive test was 1.1, 16.7, and 35, respectively. Sensitivity and specificity of the eccentric matrices were significantly better in the diagnosis of subclinical keratoconus (but not definite keratoconus) than other Pentacam indices. CONCLUSIONS: Using eccentric elevation matrix data analysis of the cornea is useful in the detection of keratoconus versus normal corneas. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40123-022-00454-6. Springer Healthcare 2022-01-15 2022-04 /pmc/articles/PMC8927558/ /pubmed/35032006 http://dx.doi.org/10.1007/s40123-022-00454-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Original Research
Tejedor, Jaime
Gutiérrez-Carmona, Francisco J.
Elevation Matrix Data in the Evaluation of Keratoconus and Normal Corneas
title Elevation Matrix Data in the Evaluation of Keratoconus and Normal Corneas
title_full Elevation Matrix Data in the Evaluation of Keratoconus and Normal Corneas
title_fullStr Elevation Matrix Data in the Evaluation of Keratoconus and Normal Corneas
title_full_unstemmed Elevation Matrix Data in the Evaluation of Keratoconus and Normal Corneas
title_short Elevation Matrix Data in the Evaluation of Keratoconus and Normal Corneas
title_sort elevation matrix data in the evaluation of keratoconus and normal corneas
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927558/
https://www.ncbi.nlm.nih.gov/pubmed/35032006
http://dx.doi.org/10.1007/s40123-022-00454-6
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