Indisulam targets RNA splicing and metabolism to serve as a therapeutic strategy for high-risk neuroblastoma

Neuroblastoma is the most common paediatric solid tumour and prognosis remains poor for high-risk cases despite the use of multimodal treatment. Analysis of public drug sensitivity data showed neuroblastoma lines to be sensitive to indisulam, a molecular glue that selectively targets RNA splicing fa...

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Detalles Bibliográficos
Autores principales: Nijhuis, Anke, Sikka, Arti, Yogev, Orli, Herendi, Lili, Balcells, Cristina, Ma, Yurui, Poon, Evon, Eckold, Clare, Valbuena, Gabriel N., Xu, Yuewei, Liu, Yusong, da Costa, Barbara Martins, Gruet, Michael, Wickremesinghe, Chiharu, Benito, Adrian, Kramer, Holger, Montoya, Alex, Carling, David, Want, Elizabeth J., Jamin, Yann, Chesler, Louis, Keun, Hector C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927615/
https://www.ncbi.nlm.nih.gov/pubmed/35296644
http://dx.doi.org/10.1038/s41467-022-28907-3

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