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Adult Height in Girls With Idiopathic Premature Adrenarche: A Cohort Study and Design of a Predictive Model
INTRODUCTION: Idiopathic premature adrenarche (IPA) is considered a normal variant of puberty, presenting more commonly in female patients. There are concerns as to whether IPA alters the final height of these girls. Our main objectives were to (a) compare the adult height of girls with IPA against...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927636/ https://www.ncbi.nlm.nih.gov/pubmed/35311244 http://dx.doi.org/10.3389/fendo.2022.852422 |
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author | Mejorado-Molano, Francisco Javier Sanz-Calvo, María Luisa Posada-Ayala, Ana Caballo-Roig, Nieves Gavela-Pérez, Teresa Mahillo-Fernández, Ignacio Soriano-Guillén, Leandro |
author_facet | Mejorado-Molano, Francisco Javier Sanz-Calvo, María Luisa Posada-Ayala, Ana Caballo-Roig, Nieves Gavela-Pérez, Teresa Mahillo-Fernández, Ignacio Soriano-Guillén, Leandro |
author_sort | Mejorado-Molano, Francisco Javier |
collection | PubMed |
description | INTRODUCTION: Idiopathic premature adrenarche (IPA) is considered a normal variant of puberty, presenting more commonly in female patients. There are concerns as to whether IPA alters the final height of these girls. Our main objectives were to (a) compare the adult height of girls with IPA against their target height and (b) design a mathematical model to predict adult height at diagnosis in female patients with IPA. MATERIALS AND METHODS: A cohort study of girls with IPA was conducted from the time of IPA diagnosis until adult height. The following data were collected: target height, perinatal history, anthropometric and biochemical variables and bone age at diagnosis, age at Tanner stage 2 and menarcheal age, and adult height. First, we performed a univariate statistical analysis after which we carried out a multiple linear regression analysis using adult height as the dependent variable. RESULTS: We obtained data from 79 female patients diagnosed with IPA with a mean adult height of 164.6 cm (95% CI: 163.36–165.85 cm). The mean follow-up time was 6.60 years. Average age at Tanner stage 2 was 9.71 years. Mean menarcheal age was 11.64 years. There were no significant differences between target height and adult height. Of the several predictive models designed for these patients, one of them, which included bone age, obtained an R (2) value of 71%. CONCLUSIONS: Although slightly advanced puberty was observed among the girls with IPA, their adult height was preserved. The use of predictive models of adult height on diagnosis of IPA could facilitate closer follow-up of girls at risk of reduced adult height. |
format | Online Article Text |
id | pubmed-8927636 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89276362022-03-18 Adult Height in Girls With Idiopathic Premature Adrenarche: A Cohort Study and Design of a Predictive Model Mejorado-Molano, Francisco Javier Sanz-Calvo, María Luisa Posada-Ayala, Ana Caballo-Roig, Nieves Gavela-Pérez, Teresa Mahillo-Fernández, Ignacio Soriano-Guillén, Leandro Front Endocrinol (Lausanne) Endocrinology INTRODUCTION: Idiopathic premature adrenarche (IPA) is considered a normal variant of puberty, presenting more commonly in female patients. There are concerns as to whether IPA alters the final height of these girls. Our main objectives were to (a) compare the adult height of girls with IPA against their target height and (b) design a mathematical model to predict adult height at diagnosis in female patients with IPA. MATERIALS AND METHODS: A cohort study of girls with IPA was conducted from the time of IPA diagnosis until adult height. The following data were collected: target height, perinatal history, anthropometric and biochemical variables and bone age at diagnosis, age at Tanner stage 2 and menarcheal age, and adult height. First, we performed a univariate statistical analysis after which we carried out a multiple linear regression analysis using adult height as the dependent variable. RESULTS: We obtained data from 79 female patients diagnosed with IPA with a mean adult height of 164.6 cm (95% CI: 163.36–165.85 cm). The mean follow-up time was 6.60 years. Average age at Tanner stage 2 was 9.71 years. Mean menarcheal age was 11.64 years. There were no significant differences between target height and adult height. Of the several predictive models designed for these patients, one of them, which included bone age, obtained an R (2) value of 71%. CONCLUSIONS: Although slightly advanced puberty was observed among the girls with IPA, their adult height was preserved. The use of predictive models of adult height on diagnosis of IPA could facilitate closer follow-up of girls at risk of reduced adult height. Frontiers Media S.A. 2022-03-03 /pmc/articles/PMC8927636/ /pubmed/35311244 http://dx.doi.org/10.3389/fendo.2022.852422 Text en Copyright © 2022 Mejorado-Molano, Sanz-Calvo, Posada-Ayala, Caballo-Roig, Gavela-Pérez, Mahillo-Fernández and Soriano-Guillén https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Mejorado-Molano, Francisco Javier Sanz-Calvo, María Luisa Posada-Ayala, Ana Caballo-Roig, Nieves Gavela-Pérez, Teresa Mahillo-Fernández, Ignacio Soriano-Guillén, Leandro Adult Height in Girls With Idiopathic Premature Adrenarche: A Cohort Study and Design of a Predictive Model |
title | Adult Height in Girls With Idiopathic Premature Adrenarche: A Cohort Study and Design of a Predictive Model |
title_full | Adult Height in Girls With Idiopathic Premature Adrenarche: A Cohort Study and Design of a Predictive Model |
title_fullStr | Adult Height in Girls With Idiopathic Premature Adrenarche: A Cohort Study and Design of a Predictive Model |
title_full_unstemmed | Adult Height in Girls With Idiopathic Premature Adrenarche: A Cohort Study and Design of a Predictive Model |
title_short | Adult Height in Girls With Idiopathic Premature Adrenarche: A Cohort Study and Design of a Predictive Model |
title_sort | adult height in girls with idiopathic premature adrenarche: a cohort study and design of a predictive model |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927636/ https://www.ncbi.nlm.nih.gov/pubmed/35311244 http://dx.doi.org/10.3389/fendo.2022.852422 |
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