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Frailty as a predictor of mortality in COVID-19 patients receiving CPAP for respiratory insufficiency

OBJECTIVE: Exploring the association between frailty and mortality in a cohort of patients with COVID-19 respiratory insufficiency treated with continuous positive airway pressure. METHODS: Frailty was measured using a Frailty Index (FI) created by using the baseline assessment data on comorbidities...

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Autores principales: Damanti, Sarah, Ramirez, Giuseppe Alvise, Bozzolo, Enrica Paola, Da Prat, Valentina, Di Lucca, Giuseppe, Di Terlizzi, Gaetano, Marinosci, Alessandro, Scotti, Raffaella, Strada, Silvia, Scarpellini, Paolo, Castiglioni, Barbara, Oltolini, Chiara, Ripa, Marco, Din, Chiara Tassan, Centurioni, Clarissa Elisabeth, Di Scala, Flavia, Gobbi, Agnese, Alba, Ada Carla, Casiraghi, Giuseppina Maria, Morgillo, Anna, Tresoldi, Moreno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927756/
https://www.ncbi.nlm.nih.gov/pubmed/35298829
http://dx.doi.org/10.1007/s40520-021-02070-z
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author Damanti, Sarah
Ramirez, Giuseppe Alvise
Bozzolo, Enrica Paola
Da Prat, Valentina
Di Lucca, Giuseppe
Di Terlizzi, Gaetano
Marinosci, Alessandro
Scotti, Raffaella
Strada, Silvia
Scarpellini, Paolo
Castiglioni, Barbara
Oltolini, Chiara
Ripa, Marco
Din, Chiara Tassan
Centurioni, Clarissa Elisabeth
Di Scala, Flavia
Gobbi, Agnese
Alba, Ada Carla
Casiraghi, Giuseppina Maria
Morgillo, Anna
Tresoldi, Moreno
author_facet Damanti, Sarah
Ramirez, Giuseppe Alvise
Bozzolo, Enrica Paola
Da Prat, Valentina
Di Lucca, Giuseppe
Di Terlizzi, Gaetano
Marinosci, Alessandro
Scotti, Raffaella
Strada, Silvia
Scarpellini, Paolo
Castiglioni, Barbara
Oltolini, Chiara
Ripa, Marco
Din, Chiara Tassan
Centurioni, Clarissa Elisabeth
Di Scala, Flavia
Gobbi, Agnese
Alba, Ada Carla
Casiraghi, Giuseppina Maria
Morgillo, Anna
Tresoldi, Moreno
author_sort Damanti, Sarah
collection PubMed
description OBJECTIVE: Exploring the association between frailty and mortality in a cohort of patients with COVID-19 respiratory insufficiency treated with continuous positive airway pressure. METHODS: Frailty was measured using a Frailty Index (FI) created by using the baseline assessment data on comorbidities and body mass index and baseline blood test results (including pH, lactate dehydrogenase, renal and liver function, inflammatory indexes and anemia). FI > 0.25 identified frail individuals. RESULTS: Among the 159 included individuals (81% men, median age of 68) frailty was detected in 69% of the patients (median FI score 0.3 ± 0.08). Frailty was associated to an increased mortality (adjusted HR 1.99, 95% CI 1.02–3.88, p = 0.04). CONCLUSIONS: Frailty is highly prevalent among patients with COVID-19, predicts poorer outcomes independently of age. A personalization of care balancing the risk and benefit of treatments (especially the invasive ones) in such complex patients is pivotal. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40520-021-02070-z.
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spelling pubmed-89277562022-03-17 Frailty as a predictor of mortality in COVID-19 patients receiving CPAP for respiratory insufficiency Damanti, Sarah Ramirez, Giuseppe Alvise Bozzolo, Enrica Paola Da Prat, Valentina Di Lucca, Giuseppe Di Terlizzi, Gaetano Marinosci, Alessandro Scotti, Raffaella Strada, Silvia Scarpellini, Paolo Castiglioni, Barbara Oltolini, Chiara Ripa, Marco Din, Chiara Tassan Centurioni, Clarissa Elisabeth Di Scala, Flavia Gobbi, Agnese Alba, Ada Carla Casiraghi, Giuseppina Maria Morgillo, Anna Tresoldi, Moreno Aging Clin Exp Res Short Communication OBJECTIVE: Exploring the association between frailty and mortality in a cohort of patients with COVID-19 respiratory insufficiency treated with continuous positive airway pressure. METHODS: Frailty was measured using a Frailty Index (FI) created by using the baseline assessment data on comorbidities and body mass index and baseline blood test results (including pH, lactate dehydrogenase, renal and liver function, inflammatory indexes and anemia). FI > 0.25 identified frail individuals. RESULTS: Among the 159 included individuals (81% men, median age of 68) frailty was detected in 69% of the patients (median FI score 0.3 ± 0.08). Frailty was associated to an increased mortality (adjusted HR 1.99, 95% CI 1.02–3.88, p = 0.04). CONCLUSIONS: Frailty is highly prevalent among patients with COVID-19, predicts poorer outcomes independently of age. A personalization of care balancing the risk and benefit of treatments (especially the invasive ones) in such complex patients is pivotal. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40520-021-02070-z. Springer International Publishing 2022-03-17 2022 /pmc/articles/PMC8927756/ /pubmed/35298829 http://dx.doi.org/10.1007/s40520-021-02070-z Text en © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Short Communication
Damanti, Sarah
Ramirez, Giuseppe Alvise
Bozzolo, Enrica Paola
Da Prat, Valentina
Di Lucca, Giuseppe
Di Terlizzi, Gaetano
Marinosci, Alessandro
Scotti, Raffaella
Strada, Silvia
Scarpellini, Paolo
Castiglioni, Barbara
Oltolini, Chiara
Ripa, Marco
Din, Chiara Tassan
Centurioni, Clarissa Elisabeth
Di Scala, Flavia
Gobbi, Agnese
Alba, Ada Carla
Casiraghi, Giuseppina Maria
Morgillo, Anna
Tresoldi, Moreno
Frailty as a predictor of mortality in COVID-19 patients receiving CPAP for respiratory insufficiency
title Frailty as a predictor of mortality in COVID-19 patients receiving CPAP for respiratory insufficiency
title_full Frailty as a predictor of mortality in COVID-19 patients receiving CPAP for respiratory insufficiency
title_fullStr Frailty as a predictor of mortality in COVID-19 patients receiving CPAP for respiratory insufficiency
title_full_unstemmed Frailty as a predictor of mortality in COVID-19 patients receiving CPAP for respiratory insufficiency
title_short Frailty as a predictor of mortality in COVID-19 patients receiving CPAP for respiratory insufficiency
title_sort frailty as a predictor of mortality in covid-19 patients receiving cpap for respiratory insufficiency
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927756/
https://www.ncbi.nlm.nih.gov/pubmed/35298829
http://dx.doi.org/10.1007/s40520-021-02070-z
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