The Role of IL-17-Mediated Inflammatory Processes in the Pathogenesis of Intervertebral Disc Degeneration and Herniation: A Comprehensive Review

It has been reported that degenerated and herniated lumbar intervertebral discs show high expression of IL-17, suggesting that local immune reactions occur in patients with low back pain. While clinical sample analyses from different laboratories confirm this, it is not deeply not known on how IL-17...

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Detalles Bibliográficos
Autores principales: Suyama, Kaori, Sakai, Daisuke, Watanabe, Masahiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927779/
https://www.ncbi.nlm.nih.gov/pubmed/35309927
http://dx.doi.org/10.3389/fcell.2022.857164
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author Suyama, Kaori
Sakai, Daisuke
Watanabe, Masahiko
author_facet Suyama, Kaori
Sakai, Daisuke
Watanabe, Masahiko
author_sort Suyama, Kaori
collection PubMed
description It has been reported that degenerated and herniated lumbar intervertebral discs show high expression of IL-17, suggesting that local immune reactions occur in patients with low back pain. While clinical sample analyses from different laboratories confirm this, it is not deeply not known on how IL-17 is induced in the pathology and their interactions with other inflammatory responses. This conscience review organizes current laboratory findings on this topic and present trajectory for full understanding on the role of IL-17 in pathology of intervertebral disc disease.
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spelling pubmed-89277792022-03-18 The Role of IL-17-Mediated Inflammatory Processes in the Pathogenesis of Intervertebral Disc Degeneration and Herniation: A Comprehensive Review Suyama, Kaori Sakai, Daisuke Watanabe, Masahiko Front Cell Dev Biol Cell and Developmental Biology It has been reported that degenerated and herniated lumbar intervertebral discs show high expression of IL-17, suggesting that local immune reactions occur in patients with low back pain. While clinical sample analyses from different laboratories confirm this, it is not deeply not known on how IL-17 is induced in the pathology and their interactions with other inflammatory responses. This conscience review organizes current laboratory findings on this topic and present trajectory for full understanding on the role of IL-17 in pathology of intervertebral disc disease. Frontiers Media S.A. 2022-03-03 /pmc/articles/PMC8927779/ /pubmed/35309927 http://dx.doi.org/10.3389/fcell.2022.857164 Text en Copyright © 2022 Suyama, Sakai and Watanabe. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Suyama, Kaori
Sakai, Daisuke
Watanabe, Masahiko
The Role of IL-17-Mediated Inflammatory Processes in the Pathogenesis of Intervertebral Disc Degeneration and Herniation: A Comprehensive Review
title The Role of IL-17-Mediated Inflammatory Processes in the Pathogenesis of Intervertebral Disc Degeneration and Herniation: A Comprehensive Review
title_full The Role of IL-17-Mediated Inflammatory Processes in the Pathogenesis of Intervertebral Disc Degeneration and Herniation: A Comprehensive Review
title_fullStr The Role of IL-17-Mediated Inflammatory Processes in the Pathogenesis of Intervertebral Disc Degeneration and Herniation: A Comprehensive Review
title_full_unstemmed The Role of IL-17-Mediated Inflammatory Processes in the Pathogenesis of Intervertebral Disc Degeneration and Herniation: A Comprehensive Review
title_short The Role of IL-17-Mediated Inflammatory Processes in the Pathogenesis of Intervertebral Disc Degeneration and Herniation: A Comprehensive Review
title_sort role of il-17-mediated inflammatory processes in the pathogenesis of intervertebral disc degeneration and herniation: a comprehensive review
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927779/
https://www.ncbi.nlm.nih.gov/pubmed/35309927
http://dx.doi.org/10.3389/fcell.2022.857164
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