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The edible plant Amaranthus hybridus (Amaranthaceae) prevents the biochemical, histopathological and fertility impairments in colibri®-treated female rats
Colibri® a commercial formulation of Imidacloprid severely impairs the reproductive function. This study aimed at evaluating the preventive effects of Amaranthus hybridus on the reproductive toxicity of colibri® in female rats. Eighty rats (n = 10/group) were orally treated with colibri® (22.5 mg/kg...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927798/ https://www.ncbi.nlm.nih.gov/pubmed/35310145 http://dx.doi.org/10.1016/j.toxrep.2022.03.014 |
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author | Nsamou, Prechmy Carole Ngueyong Momo, Aimé Césaire Tetsatsi Tchatat, Yannick Baudouin Petnga Fozin, Georges Romeo Bonsou Kemka, François Xavier Ngadjui, Esther Watcho, Pierre |
author_facet | Nsamou, Prechmy Carole Ngueyong Momo, Aimé Césaire Tetsatsi Tchatat, Yannick Baudouin Petnga Fozin, Georges Romeo Bonsou Kemka, François Xavier Ngadjui, Esther Watcho, Pierre |
author_sort | Nsamou, Prechmy Carole Ngueyong |
collection | PubMed |
description | Colibri® a commercial formulation of Imidacloprid severely impairs the reproductive function. This study aimed at evaluating the preventive effects of Amaranthus hybridus on the reproductive toxicity of colibri® in female rats. Eighty rats (n = 10/group) were orally treated with colibri® (22.5 mg/kg) and co-administered with either aqueous or methanolic extracts of A. hybridus (55 or 110 mg/kg) within four weeks. Control animals received either distilled water (10 ml/kg), clomiphene citrate or vitamin E. Starting from day 18 of treatment till the end, half of animals in each group (n = 5) was used for the fertility test whereas the remaining rats were kept under treatment until sacrifice. Blood, ovaries, uterus and vagina were collected after sacrifice for measurement of sexual hormones, oxidative stress markers and histological assessment. Exposure of female rats to colibri® was followed by a significant reduction (p < 0.05) in the ovarian and uterine weights, LH, FSH, estradiol and progesterone levels as well as ovarian superoxide dismutase, catalase and peroxidase activities. Moreover, alteration of ovaries, uteri and vagina histology, increase in MDA concentration, decrease in fertility and parturition indices and, pup’s viability were recorded. Co-administration of colibri® and plant extracts significantly (p < 0.05–0.001) prevented the above-mentioned damages through biochemical parameter regulations. These results suggest that A. hybridus exerts a preventive effect against colibri®-induced female reproductive toxicity. |
format | Online Article Text |
id | pubmed-8927798 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-89277982022-03-18 The edible plant Amaranthus hybridus (Amaranthaceae) prevents the biochemical, histopathological and fertility impairments in colibri®-treated female rats Nsamou, Prechmy Carole Ngueyong Momo, Aimé Césaire Tetsatsi Tchatat, Yannick Baudouin Petnga Fozin, Georges Romeo Bonsou Kemka, François Xavier Ngadjui, Esther Watcho, Pierre Toxicol Rep Regular Article Colibri® a commercial formulation of Imidacloprid severely impairs the reproductive function. This study aimed at evaluating the preventive effects of Amaranthus hybridus on the reproductive toxicity of colibri® in female rats. Eighty rats (n = 10/group) were orally treated with colibri® (22.5 mg/kg) and co-administered with either aqueous or methanolic extracts of A. hybridus (55 or 110 mg/kg) within four weeks. Control animals received either distilled water (10 ml/kg), clomiphene citrate or vitamin E. Starting from day 18 of treatment till the end, half of animals in each group (n = 5) was used for the fertility test whereas the remaining rats were kept under treatment until sacrifice. Blood, ovaries, uterus and vagina were collected after sacrifice for measurement of sexual hormones, oxidative stress markers and histological assessment. Exposure of female rats to colibri® was followed by a significant reduction (p < 0.05) in the ovarian and uterine weights, LH, FSH, estradiol and progesterone levels as well as ovarian superoxide dismutase, catalase and peroxidase activities. Moreover, alteration of ovaries, uteri and vagina histology, increase in MDA concentration, decrease in fertility and parturition indices and, pup’s viability were recorded. Co-administration of colibri® and plant extracts significantly (p < 0.05–0.001) prevented the above-mentioned damages through biochemical parameter regulations. These results suggest that A. hybridus exerts a preventive effect against colibri®-induced female reproductive toxicity. Elsevier 2022-03-08 /pmc/articles/PMC8927798/ /pubmed/35310145 http://dx.doi.org/10.1016/j.toxrep.2022.03.014 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Regular Article Nsamou, Prechmy Carole Ngueyong Momo, Aimé Césaire Tetsatsi Tchatat, Yannick Baudouin Petnga Fozin, Georges Romeo Bonsou Kemka, François Xavier Ngadjui, Esther Watcho, Pierre The edible plant Amaranthus hybridus (Amaranthaceae) prevents the biochemical, histopathological and fertility impairments in colibri®-treated female rats |
title | The edible plant Amaranthus hybridus (Amaranthaceae) prevents the biochemical, histopathological and fertility impairments in colibri®-treated female rats |
title_full | The edible plant Amaranthus hybridus (Amaranthaceae) prevents the biochemical, histopathological and fertility impairments in colibri®-treated female rats |
title_fullStr | The edible plant Amaranthus hybridus (Amaranthaceae) prevents the biochemical, histopathological and fertility impairments in colibri®-treated female rats |
title_full_unstemmed | The edible plant Amaranthus hybridus (Amaranthaceae) prevents the biochemical, histopathological and fertility impairments in colibri®-treated female rats |
title_short | The edible plant Amaranthus hybridus (Amaranthaceae) prevents the biochemical, histopathological and fertility impairments in colibri®-treated female rats |
title_sort | edible plant amaranthus hybridus (amaranthaceae) prevents the biochemical, histopathological and fertility impairments in colibri®-treated female rats |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927798/ https://www.ncbi.nlm.nih.gov/pubmed/35310145 http://dx.doi.org/10.1016/j.toxrep.2022.03.014 |
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