Protocol for recording epileptiform discharges of EEG and behavioral seizures in freely moving mice

Recurrent seizures are a common feature in many neurologic disorders. Seizure examination may help with diagnosis, preclinical study, and development of treatment strategies. Here we detail protocols to prepare and implant electrodes, as well as to record and analyze seizure events in freely moving...

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Autores principales: Wang, Qi, de Prisco, Nicola, Tang, Jianrong, Gennarino, Vincenzo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927982/
https://www.ncbi.nlm.nih.gov/pubmed/35310070
http://dx.doi.org/10.1016/j.xpro.2022.101245
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author Wang, Qi
de Prisco, Nicola
Tang, Jianrong
Gennarino, Vincenzo A.
author_facet Wang, Qi
de Prisco, Nicola
Tang, Jianrong
Gennarino, Vincenzo A.
author_sort Wang, Qi
collection PubMed
description Recurrent seizures are a common feature in many neurologic disorders. Seizure examination may help with diagnosis, preclinical study, and development of treatment strategies. Here we detail protocols to prepare and implant electrodes, as well as to record and analyze seizure events in freely moving mice. SCA47 mice exhibit both preclinical seizures (i.e., epileptiform discharges of EEG) starting from ∼14 weeks of age and behavioral seizures (i.e., spontaneous behavioral seizures) starting from ∼22 weeks of age. For complete details on the use and execution of this protocol, please refer to Gennarino et al. (2018).
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spelling pubmed-89279822022-03-18 Protocol for recording epileptiform discharges of EEG and behavioral seizures in freely moving mice Wang, Qi de Prisco, Nicola Tang, Jianrong Gennarino, Vincenzo A. STAR Protoc Protocol Recurrent seizures are a common feature in many neurologic disorders. Seizure examination may help with diagnosis, preclinical study, and development of treatment strategies. Here we detail protocols to prepare and implant electrodes, as well as to record and analyze seizure events in freely moving mice. SCA47 mice exhibit both preclinical seizures (i.e., epileptiform discharges of EEG) starting from ∼14 weeks of age and behavioral seizures (i.e., spontaneous behavioral seizures) starting from ∼22 weeks of age. For complete details on the use and execution of this protocol, please refer to Gennarino et al. (2018). Elsevier 2022-03-14 /pmc/articles/PMC8927982/ /pubmed/35310070 http://dx.doi.org/10.1016/j.xpro.2022.101245 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Protocol
Wang, Qi
de Prisco, Nicola
Tang, Jianrong
Gennarino, Vincenzo A.
Protocol for recording epileptiform discharges of EEG and behavioral seizures in freely moving mice
title Protocol for recording epileptiform discharges of EEG and behavioral seizures in freely moving mice
title_full Protocol for recording epileptiform discharges of EEG and behavioral seizures in freely moving mice
title_fullStr Protocol for recording epileptiform discharges of EEG and behavioral seizures in freely moving mice
title_full_unstemmed Protocol for recording epileptiform discharges of EEG and behavioral seizures in freely moving mice
title_short Protocol for recording epileptiform discharges of EEG and behavioral seizures in freely moving mice
title_sort protocol for recording epileptiform discharges of eeg and behavioral seizures in freely moving mice
topic Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927982/
https://www.ncbi.nlm.nih.gov/pubmed/35310070
http://dx.doi.org/10.1016/j.xpro.2022.101245
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