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SHP2 allosteric inhibitor TK-453 alleviates psoriasis-like skin inflammation in mice via inhibition of IL-23/Th17 axis

SHP2 is the first oncogenic tyrosine phosphatase encoded by PTPN11, which plays a significant regulatory role in cancer and inflammation-related diseases. Although SHP2 allosteric inhibitors have been used in phase I/II clinical trials for solid tumors, whether SHP2 inhibition alleviates psoriasis r...

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Detalles Bibliográficos
Autores principales:	Wang, Meijing, Li, Tinghan, Ouyang, Zijun, Tang, Kai, Zhu, Yuyu, Song, Chenglin, Sun, Haiyan, Yu, Bin, Ji, Xiaoyun, Sun, Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927994/ https://www.ncbi.nlm.nih.gov/pubmed/35310939 http://dx.doi.org/10.1016/j.isci.2022.104009

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