Structural and functional insights into the inhibition of human voltage-gated sodium channels by μ-conotoxin KIIIA disulfide isomers

μ-Conotoxins are components of cone snail venom, well-known for their analgesic activity through potent inhibition of voltage-gated sodium channel (Na(V)) subtypes, including Na(V)1.7. These small, disulfide-rich peptides are typically stabilized by three disulfide bonds arranged in a ‘native’ CysI-...

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Detalles Bibliográficos
Autores principales: Tran, Hue N.T., McMahon, Kirsten L., Deuis, Jennifer R., Vetter, Irina, Schroeder, Christina I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927997/
https://www.ncbi.nlm.nih.gov/pubmed/35167877
http://dx.doi.org/10.1016/j.jbc.2022.101728

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