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Virulence Mechanisms of Mycobacterium abscessus: Current Knowledge and Implications for Vaccine Design
Mycobacterium abscessus is a member of the non-tuberculous mycobacteria (NTM) group, responsible for chronic infections in individuals with cystic fibrosis (CF) or those otherwise immunocompromised. While viewed traditionally as an opportunistic pathogen, increasing research into M. abscessus in rec...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8928063/ https://www.ncbi.nlm.nih.gov/pubmed/35308378 http://dx.doi.org/10.3389/fmicb.2022.842017 |
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author | Ferrell, Kia C. Johansen, Matt D. Triccas, James A. Counoupas, Claudio |
author_facet | Ferrell, Kia C. Johansen, Matt D. Triccas, James A. Counoupas, Claudio |
author_sort | Ferrell, Kia C. |
collection | PubMed |
description | Mycobacterium abscessus is a member of the non-tuberculous mycobacteria (NTM) group, responsible for chronic infections in individuals with cystic fibrosis (CF) or those otherwise immunocompromised. While viewed traditionally as an opportunistic pathogen, increasing research into M. abscessus in recent years has highlighted its continued evolution into a true pathogen. This is demonstrated through an extensive collection of virulence factors (VFs) possessed by this organism which facilitate survival within the host, particularly in the harsh environment of the CF lung. These include VFs resembling those of other Mycobacteria, and non-mycobacterial VFs, both of which make a notable contribution in shaping M. abscessus interaction with the host. Mycobacterium abscessus continued acquisition of VFs is cause for concern and highlights the need for novel vaccination strategies to combat this pathogen. An effective M. abscessus vaccine must be suitably designed for target populations (i.e., individuals with CF) and incorporate current knowledge on immune correlates of protection against M. abscessus infection. Vaccination strategies must also build upon lessons learned from ongoing efforts to develop novel vaccines for other pathogens, particularly Mycobacterium tuberculosis (M. tb); decades of research into M. tb has provided insight into unconventional and innovative vaccine approaches that may be applied to M. abscessus. Continued research into M. abscessus pathogenesis will be critical for the future development of safe and effective vaccines and therapeutics to reduce global incidence of this emerging pathogen. |
format | Online Article Text |
id | pubmed-8928063 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89280632022-03-18 Virulence Mechanisms of Mycobacterium abscessus: Current Knowledge and Implications for Vaccine Design Ferrell, Kia C. Johansen, Matt D. Triccas, James A. Counoupas, Claudio Front Microbiol Microbiology Mycobacterium abscessus is a member of the non-tuberculous mycobacteria (NTM) group, responsible for chronic infections in individuals with cystic fibrosis (CF) or those otherwise immunocompromised. While viewed traditionally as an opportunistic pathogen, increasing research into M. abscessus in recent years has highlighted its continued evolution into a true pathogen. This is demonstrated through an extensive collection of virulence factors (VFs) possessed by this organism which facilitate survival within the host, particularly in the harsh environment of the CF lung. These include VFs resembling those of other Mycobacteria, and non-mycobacterial VFs, both of which make a notable contribution in shaping M. abscessus interaction with the host. Mycobacterium abscessus continued acquisition of VFs is cause for concern and highlights the need for novel vaccination strategies to combat this pathogen. An effective M. abscessus vaccine must be suitably designed for target populations (i.e., individuals with CF) and incorporate current knowledge on immune correlates of protection against M. abscessus infection. Vaccination strategies must also build upon lessons learned from ongoing efforts to develop novel vaccines for other pathogens, particularly Mycobacterium tuberculosis (M. tb); decades of research into M. tb has provided insight into unconventional and innovative vaccine approaches that may be applied to M. abscessus. Continued research into M. abscessus pathogenesis will be critical for the future development of safe and effective vaccines and therapeutics to reduce global incidence of this emerging pathogen. Frontiers Media S.A. 2022-03-03 /pmc/articles/PMC8928063/ /pubmed/35308378 http://dx.doi.org/10.3389/fmicb.2022.842017 Text en Copyright © 2022 Ferrell, Johansen, Triccas and Counoupas. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Ferrell, Kia C. Johansen, Matt D. Triccas, James A. Counoupas, Claudio Virulence Mechanisms of Mycobacterium abscessus: Current Knowledge and Implications for Vaccine Design |
title | Virulence Mechanisms of Mycobacterium abscessus: Current Knowledge and Implications for Vaccine Design |
title_full | Virulence Mechanisms of Mycobacterium abscessus: Current Knowledge and Implications for Vaccine Design |
title_fullStr | Virulence Mechanisms of Mycobacterium abscessus: Current Knowledge and Implications for Vaccine Design |
title_full_unstemmed | Virulence Mechanisms of Mycobacterium abscessus: Current Knowledge and Implications for Vaccine Design |
title_short | Virulence Mechanisms of Mycobacterium abscessus: Current Knowledge and Implications for Vaccine Design |
title_sort | virulence mechanisms of mycobacterium abscessus: current knowledge and implications for vaccine design |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8928063/ https://www.ncbi.nlm.nih.gov/pubmed/35308378 http://dx.doi.org/10.3389/fmicb.2022.842017 |
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