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The Risk of Gout in Patients with Psoriasis: A Population-Based Cohort Study in Taiwan

BACKGROUND: Previous research has pointed to the relationship between psoriasis and the development of gout. However, most previous studies had either small sample sizes or short study durations. Therefore, in this nationwide cohort study, we investigated the effect of psoriasis on the risk of gout...

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Autores principales: Wei, James Cheng-Chung, Chang, Yi-Jung, Wang, Yu-Hsun, Yeh, Chih-Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8928107/
https://www.ncbi.nlm.nih.gov/pubmed/35309101
http://dx.doi.org/10.2147/CLEP.S346128
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author Wei, James Cheng-Chung
Chang, Yi-Jung
Wang, Yu-Hsun
Yeh, Chih-Jung
author_facet Wei, James Cheng-Chung
Chang, Yi-Jung
Wang, Yu-Hsun
Yeh, Chih-Jung
author_sort Wei, James Cheng-Chung
collection PubMed
description BACKGROUND: Previous research has pointed to the relationship between psoriasis and the development of gout. However, most previous studies had either small sample sizes or short study durations. Therefore, in this nationwide cohort study, we investigated the effect of psoriasis on the risk of gout development. METHODS: The study group included one million patients from Taiwan, whom we followed for 14 years. The participants were divided into two cohorts designated as psoriasis and non-psoriasis. A 1:4 propensity score matching test was used to compare age, sex, and index year between the two cohorts. Cox proportional hazard regression was used to determine the hazard ratios (HRs) and 95% confidence intervals (CIs) for the risk of gout. Sensitivity analyses were conducted to evaluate the HR for gout after the occurrence of psoriasis. RESULTS: The incidence densities of gout in the psoriasis and non-psoriasis cohorts were 6.96 and 5.09 per 1000 person-years, respectively. After adjusting for age, sex, urbanization, comorbidities, and nonsteroidal anti-inflammatory drug (NSAID) use, the adjusted hazard ratio (aHR) with 95% CI for incidental gout in the psoriasis group was 1.38 (1.2–1.6). Moreover, the aHR (95% CI) values for gout risk in patients with psoriasis using NSAIDs and those who did not were 1.21 (1.0–1.47) and 1.65 (1.33–2.05), respectively. CONCLUSION: This study demonstrated an association between psoriasis and risk of developing gout. Clinically, patients with psoriasis should be evaluated for incidental gout.
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spelling pubmed-89281072022-03-18 The Risk of Gout in Patients with Psoriasis: A Population-Based Cohort Study in Taiwan Wei, James Cheng-Chung Chang, Yi-Jung Wang, Yu-Hsun Yeh, Chih-Jung Clin Epidemiol Original Research BACKGROUND: Previous research has pointed to the relationship between psoriasis and the development of gout. However, most previous studies had either small sample sizes or short study durations. Therefore, in this nationwide cohort study, we investigated the effect of psoriasis on the risk of gout development. METHODS: The study group included one million patients from Taiwan, whom we followed for 14 years. The participants were divided into two cohorts designated as psoriasis and non-psoriasis. A 1:4 propensity score matching test was used to compare age, sex, and index year between the two cohorts. Cox proportional hazard regression was used to determine the hazard ratios (HRs) and 95% confidence intervals (CIs) for the risk of gout. Sensitivity analyses were conducted to evaluate the HR for gout after the occurrence of psoriasis. RESULTS: The incidence densities of gout in the psoriasis and non-psoriasis cohorts were 6.96 and 5.09 per 1000 person-years, respectively. After adjusting for age, sex, urbanization, comorbidities, and nonsteroidal anti-inflammatory drug (NSAID) use, the adjusted hazard ratio (aHR) with 95% CI for incidental gout in the psoriasis group was 1.38 (1.2–1.6). Moreover, the aHR (95% CI) values for gout risk in patients with psoriasis using NSAIDs and those who did not were 1.21 (1.0–1.47) and 1.65 (1.33–2.05), respectively. CONCLUSION: This study demonstrated an association between psoriasis and risk of developing gout. Clinically, patients with psoriasis should be evaluated for incidental gout. Dove 2022-03-08 /pmc/articles/PMC8928107/ /pubmed/35309101 http://dx.doi.org/10.2147/CLEP.S346128 Text en © 2022 Wei et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Wei, James Cheng-Chung
Chang, Yi-Jung
Wang, Yu-Hsun
Yeh, Chih-Jung
The Risk of Gout in Patients with Psoriasis: A Population-Based Cohort Study in Taiwan
title The Risk of Gout in Patients with Psoriasis: A Population-Based Cohort Study in Taiwan
title_full The Risk of Gout in Patients with Psoriasis: A Population-Based Cohort Study in Taiwan
title_fullStr The Risk of Gout in Patients with Psoriasis: A Population-Based Cohort Study in Taiwan
title_full_unstemmed The Risk of Gout in Patients with Psoriasis: A Population-Based Cohort Study in Taiwan
title_short The Risk of Gout in Patients with Psoriasis: A Population-Based Cohort Study in Taiwan
title_sort risk of gout in patients with psoriasis: a population-based cohort study in taiwan
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8928107/
https://www.ncbi.nlm.nih.gov/pubmed/35309101
http://dx.doi.org/10.2147/CLEP.S346128
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