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Haemophagocytic lymphohistiocytosis following COVID-19 mRNA vaccination

The development of vaccinations has been instrumental in the ongoing effort to combat the COVID-19 pandemic. Although the benefits of vaccination are unquestionable, there have been reports of potentially rare life-threatening complications following vaccination including thrombocytopaenia, haemolyt...

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Autores principales: Wu, Vernon, Lopez, Carlos A, Hines, Adam M, Barrientos, Jacqueline C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8928286/
https://www.ncbi.nlm.nih.gov/pubmed/35296502
http://dx.doi.org/10.1136/bcr-2021-247022
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author Wu, Vernon
Lopez, Carlos A
Hines, Adam M
Barrientos, Jacqueline C
author_facet Wu, Vernon
Lopez, Carlos A
Hines, Adam M
Barrientos, Jacqueline C
author_sort Wu, Vernon
collection PubMed
description The development of vaccinations has been instrumental in the ongoing effort to combat the COVID-19 pandemic. Although the benefits of vaccination are unquestionable, there have been reports of potentially rare life-threatening complications following vaccination including thrombocytopaenia, haemolytic anaemia, vasculitis and myocarditis. Haemophagocytic lymphohistiocytosis (HLH), a rare but life-threatening inflammatory condition, has also been described postadenoviral vector COVID-19 vaccination but it has never been reported post-messenger RNA (mRNA) COVID-19 vaccination. We report two cases of HLH admitted to our hospital after administration of COVID-19 mRNA vaccines. We also searched the vaccine adverse event reporting system and found 50 reports of suspected HLH following COVID-19 vaccination. Presently, we cannot define a causality between COVID-19 mRNA vaccination and HLH development. However, we hope the reporting of our two cases (and additional cases seen in the adverse event reporting database) will help us determine whether there is a potential relationship. Prompt recognition of this condition is of utmost importance to initiate life-saving therapy.
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spelling pubmed-89282862022-04-01 Haemophagocytic lymphohistiocytosis following COVID-19 mRNA vaccination Wu, Vernon Lopez, Carlos A Hines, Adam M Barrientos, Jacqueline C BMJ Case Rep Case Reports: Adverse drug reactions and complications The development of vaccinations has been instrumental in the ongoing effort to combat the COVID-19 pandemic. Although the benefits of vaccination are unquestionable, there have been reports of potentially rare life-threatening complications following vaccination including thrombocytopaenia, haemolytic anaemia, vasculitis and myocarditis. Haemophagocytic lymphohistiocytosis (HLH), a rare but life-threatening inflammatory condition, has also been described postadenoviral vector COVID-19 vaccination but it has never been reported post-messenger RNA (mRNA) COVID-19 vaccination. We report two cases of HLH admitted to our hospital after administration of COVID-19 mRNA vaccines. We also searched the vaccine adverse event reporting system and found 50 reports of suspected HLH following COVID-19 vaccination. Presently, we cannot define a causality between COVID-19 mRNA vaccination and HLH development. However, we hope the reporting of our two cases (and additional cases seen in the adverse event reporting database) will help us determine whether there is a potential relationship. Prompt recognition of this condition is of utmost importance to initiate life-saving therapy. BMJ Publishing Group 2022-03-16 /pmc/articles/PMC8928286/ /pubmed/35296502 http://dx.doi.org/10.1136/bcr-2021-247022 Text en © BMJ Publishing Group Limited 2022. No commercial re-use. See rights and permissions. Published by BMJ.
spellingShingle Case Reports: Adverse drug reactions and complications
Wu, Vernon
Lopez, Carlos A
Hines, Adam M
Barrientos, Jacqueline C
Haemophagocytic lymphohistiocytosis following COVID-19 mRNA vaccination
title Haemophagocytic lymphohistiocytosis following COVID-19 mRNA vaccination
title_full Haemophagocytic lymphohistiocytosis following COVID-19 mRNA vaccination
title_fullStr Haemophagocytic lymphohistiocytosis following COVID-19 mRNA vaccination
title_full_unstemmed Haemophagocytic lymphohistiocytosis following COVID-19 mRNA vaccination
title_short Haemophagocytic lymphohistiocytosis following COVID-19 mRNA vaccination
title_sort haemophagocytic lymphohistiocytosis following covid-19 mrna vaccination
topic Case Reports: Adverse drug reactions and complications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8928286/
https://www.ncbi.nlm.nih.gov/pubmed/35296502
http://dx.doi.org/10.1136/bcr-2021-247022
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