Oncolytic Orf virus licenses NK cells via cDC1 to activate innate and adaptive antitumor mechanisms and extends survival in a murine model of late-stage ovarian cancer

BACKGROUND: Novel therapies are needed to improve outcomes for women diagnosed with ovarian cancer. Oncolytic viruses are multifunctional immunotherapeutic biologics that preferentially infect cancer cells and stimulate inflammation with the potential to generate antitumor immunity. Herein we descri...

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Detalles Bibliográficos
Autores principales: van Vloten, Jacob P, Matuszewska, Kathy, Minow, Mark A A, Minott, Jessica A, Santry, Lisa A, Pereira, Madison, Stegelmeier, Ashley A, McAusland, Thomas M, Klafuric, Elaine M, Karimi, Khalil, Colasanti, Joseph, McFadden, D Grant, Petrik, James J, Bridle, Byram W, Wootton, Sarah K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Oncolytic and Local Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8928368/
https://www.ncbi.nlm.nih.gov/pubmed/35296558
http://dx.doi.org/10.1136/jitc-2021-004335

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