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Specific Flavonoids and Their Biosynthetic Pathway in Scutellaria baicalensis

Scutellaria baicalensis, is one of the most traditional medicinal plants in the Lamiaceae family, and has been widely used to treat liver and lung complaints and as a complementary cancer treatment in traditional Chinese medicine. The preparation from its roots, called “Huang Qin,” is rich in specia...

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Autores principales: Pei, Tianlin, Yan, Mengxiao, Huang, Yanbo, Wei, Yukun, Martin, Cathie, Zhao, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8928390/
https://www.ncbi.nlm.nih.gov/pubmed/35310641
http://dx.doi.org/10.3389/fpls.2022.866282
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author Pei, Tianlin
Yan, Mengxiao
Huang, Yanbo
Wei, Yukun
Martin, Cathie
Zhao, Qing
author_facet Pei, Tianlin
Yan, Mengxiao
Huang, Yanbo
Wei, Yukun
Martin, Cathie
Zhao, Qing
author_sort Pei, Tianlin
collection PubMed
description Scutellaria baicalensis, is one of the most traditional medicinal plants in the Lamiaceae family, and has been widely used to treat liver and lung complaints and as a complementary cancer treatment in traditional Chinese medicine. The preparation from its roots, called “Huang Qin,” is rich in specialized flavones such as baicalein, wogonin, and their glycosides which lack a 4′-hydroxyl group on the B ring (4′-deoxyflavones), with anti-tumor, antioxidant, and antiviral activities. Baicalein has recently been reported to inhibit the replication of the COVID-19 virus. These 4′-deoxyflavones are found only in the order Lamiales and were discovered in the genus Scutellaria, suggesting that a new metabolic pathway synthesizing 4′-deoxyflavones evolved recently in this genus. In this review, we focus on the class of 4′-deoxyflavones in S. baicalensis and their pharmacological properties. We also describe the apparent evolutionary route taken by the genes encoding enzymes involved in the novel, root-specific, biosynthetic pathway for baicalein and wogonin, which provides insights into the evolution of specific flavone biosynthetic pathways in the mint family.
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spelling pubmed-89283902022-03-18 Specific Flavonoids and Their Biosynthetic Pathway in Scutellaria baicalensis Pei, Tianlin Yan, Mengxiao Huang, Yanbo Wei, Yukun Martin, Cathie Zhao, Qing Front Plant Sci Plant Science Scutellaria baicalensis, is one of the most traditional medicinal plants in the Lamiaceae family, and has been widely used to treat liver and lung complaints and as a complementary cancer treatment in traditional Chinese medicine. The preparation from its roots, called “Huang Qin,” is rich in specialized flavones such as baicalein, wogonin, and their glycosides which lack a 4′-hydroxyl group on the B ring (4′-deoxyflavones), with anti-tumor, antioxidant, and antiviral activities. Baicalein has recently been reported to inhibit the replication of the COVID-19 virus. These 4′-deoxyflavones are found only in the order Lamiales and were discovered in the genus Scutellaria, suggesting that a new metabolic pathway synthesizing 4′-deoxyflavones evolved recently in this genus. In this review, we focus on the class of 4′-deoxyflavones in S. baicalensis and their pharmacological properties. We also describe the apparent evolutionary route taken by the genes encoding enzymes involved in the novel, root-specific, biosynthetic pathway for baicalein and wogonin, which provides insights into the evolution of specific flavone biosynthetic pathways in the mint family. Frontiers Media S.A. 2022-03-03 /pmc/articles/PMC8928390/ /pubmed/35310641 http://dx.doi.org/10.3389/fpls.2022.866282 Text en Copyright © 2022 Pei, Yan, Huang, Wei, Martin and Zhao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Plant Science
Pei, Tianlin
Yan, Mengxiao
Huang, Yanbo
Wei, Yukun
Martin, Cathie
Zhao, Qing
Specific Flavonoids and Their Biosynthetic Pathway in Scutellaria baicalensis
title Specific Flavonoids and Their Biosynthetic Pathway in Scutellaria baicalensis
title_full Specific Flavonoids and Their Biosynthetic Pathway in Scutellaria baicalensis
title_fullStr Specific Flavonoids and Their Biosynthetic Pathway in Scutellaria baicalensis
title_full_unstemmed Specific Flavonoids and Their Biosynthetic Pathway in Scutellaria baicalensis
title_short Specific Flavonoids and Their Biosynthetic Pathway in Scutellaria baicalensis
title_sort specific flavonoids and their biosynthetic pathway in scutellaria baicalensis
topic Plant Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8928390/
https://www.ncbi.nlm.nih.gov/pubmed/35310641
http://dx.doi.org/10.3389/fpls.2022.866282
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