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Specific Flavonoids and Their Biosynthetic Pathway in Scutellaria baicalensis
Scutellaria baicalensis, is one of the most traditional medicinal plants in the Lamiaceae family, and has been widely used to treat liver and lung complaints and as a complementary cancer treatment in traditional Chinese medicine. The preparation from its roots, called “Huang Qin,” is rich in specia...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8928390/ https://www.ncbi.nlm.nih.gov/pubmed/35310641 http://dx.doi.org/10.3389/fpls.2022.866282 |
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author | Pei, Tianlin Yan, Mengxiao Huang, Yanbo Wei, Yukun Martin, Cathie Zhao, Qing |
author_facet | Pei, Tianlin Yan, Mengxiao Huang, Yanbo Wei, Yukun Martin, Cathie Zhao, Qing |
author_sort | Pei, Tianlin |
collection | PubMed |
description | Scutellaria baicalensis, is one of the most traditional medicinal plants in the Lamiaceae family, and has been widely used to treat liver and lung complaints and as a complementary cancer treatment in traditional Chinese medicine. The preparation from its roots, called “Huang Qin,” is rich in specialized flavones such as baicalein, wogonin, and their glycosides which lack a 4′-hydroxyl group on the B ring (4′-deoxyflavones), with anti-tumor, antioxidant, and antiviral activities. Baicalein has recently been reported to inhibit the replication of the COVID-19 virus. These 4′-deoxyflavones are found only in the order Lamiales and were discovered in the genus Scutellaria, suggesting that a new metabolic pathway synthesizing 4′-deoxyflavones evolved recently in this genus. In this review, we focus on the class of 4′-deoxyflavones in S. baicalensis and their pharmacological properties. We also describe the apparent evolutionary route taken by the genes encoding enzymes involved in the novel, root-specific, biosynthetic pathway for baicalein and wogonin, which provides insights into the evolution of specific flavone biosynthetic pathways in the mint family. |
format | Online Article Text |
id | pubmed-8928390 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89283902022-03-18 Specific Flavonoids and Their Biosynthetic Pathway in Scutellaria baicalensis Pei, Tianlin Yan, Mengxiao Huang, Yanbo Wei, Yukun Martin, Cathie Zhao, Qing Front Plant Sci Plant Science Scutellaria baicalensis, is one of the most traditional medicinal plants in the Lamiaceae family, and has been widely used to treat liver and lung complaints and as a complementary cancer treatment in traditional Chinese medicine. The preparation from its roots, called “Huang Qin,” is rich in specialized flavones such as baicalein, wogonin, and their glycosides which lack a 4′-hydroxyl group on the B ring (4′-deoxyflavones), with anti-tumor, antioxidant, and antiviral activities. Baicalein has recently been reported to inhibit the replication of the COVID-19 virus. These 4′-deoxyflavones are found only in the order Lamiales and were discovered in the genus Scutellaria, suggesting that a new metabolic pathway synthesizing 4′-deoxyflavones evolved recently in this genus. In this review, we focus on the class of 4′-deoxyflavones in S. baicalensis and their pharmacological properties. We also describe the apparent evolutionary route taken by the genes encoding enzymes involved in the novel, root-specific, biosynthetic pathway for baicalein and wogonin, which provides insights into the evolution of specific flavone biosynthetic pathways in the mint family. Frontiers Media S.A. 2022-03-03 /pmc/articles/PMC8928390/ /pubmed/35310641 http://dx.doi.org/10.3389/fpls.2022.866282 Text en Copyright © 2022 Pei, Yan, Huang, Wei, Martin and Zhao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Plant Science Pei, Tianlin Yan, Mengxiao Huang, Yanbo Wei, Yukun Martin, Cathie Zhao, Qing Specific Flavonoids and Their Biosynthetic Pathway in Scutellaria baicalensis |
title | Specific Flavonoids and Their Biosynthetic Pathway in Scutellaria baicalensis |
title_full | Specific Flavonoids and Their Biosynthetic Pathway in Scutellaria baicalensis |
title_fullStr | Specific Flavonoids and Their Biosynthetic Pathway in Scutellaria baicalensis |
title_full_unstemmed | Specific Flavonoids and Their Biosynthetic Pathway in Scutellaria baicalensis |
title_short | Specific Flavonoids and Their Biosynthetic Pathway in Scutellaria baicalensis |
title_sort | specific flavonoids and their biosynthetic pathway in scutellaria baicalensis |
topic | Plant Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8928390/ https://www.ncbi.nlm.nih.gov/pubmed/35310641 http://dx.doi.org/10.3389/fpls.2022.866282 |
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