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Association of the Microbiota and Pancreatic Cancer: Opportunities and Limitations

The human body is thoroughly colonized by a wide variety of microorganisms, termed microbiota. Pancreatic cancer, one of the most aggressive forms of cancer, is no exception. The microbiota of pancreatic cancer largely influences and even dominates the occurrence, development and outcome of pancreat...

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Detalles Bibliográficos
Autores principales: Chen, Zhou, Zhang, Shaofeng, Dong, Shi, Xu, Hao, Zhou, Wence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8928443/
https://www.ncbi.nlm.nih.gov/pubmed/35309293
http://dx.doi.org/10.3389/fimmu.2022.844401
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author Chen, Zhou
Zhang, Shaofeng
Dong, Shi
Xu, Hao
Zhou, Wence
author_facet Chen, Zhou
Zhang, Shaofeng
Dong, Shi
Xu, Hao
Zhou, Wence
author_sort Chen, Zhou
collection PubMed
description The human body is thoroughly colonized by a wide variety of microorganisms, termed microbiota. Pancreatic cancer, one of the most aggressive forms of cancer, is no exception. The microbiota of pancreatic cancer largely influences and even dominates the occurrence, development and outcome of pancreatic cancer in many ways. Studies have shown that microbiota could change the malignant phenotype and prognosis of pancreatic cancer by stimulating persistent inflammation, regulating the antitumor immune system, changing the tumor microenvironment and affecting cellular metabolism. This is why the association of the microbiota with pancreatic cancer is an emerging area of research that warrants further exploration. Herein, we investigated the potential microbial markers of pancreatic cancer, related research models, the mechanism of action of microbiota in pancreatic cancer, and pancreatic cancer-microbiota-related treatment.
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spelling pubmed-89284432022-03-18 Association of the Microbiota and Pancreatic Cancer: Opportunities and Limitations Chen, Zhou Zhang, Shaofeng Dong, Shi Xu, Hao Zhou, Wence Front Immunol Immunology The human body is thoroughly colonized by a wide variety of microorganisms, termed microbiota. Pancreatic cancer, one of the most aggressive forms of cancer, is no exception. The microbiota of pancreatic cancer largely influences and even dominates the occurrence, development and outcome of pancreatic cancer in many ways. Studies have shown that microbiota could change the malignant phenotype and prognosis of pancreatic cancer by stimulating persistent inflammation, regulating the antitumor immune system, changing the tumor microenvironment and affecting cellular metabolism. This is why the association of the microbiota with pancreatic cancer is an emerging area of research that warrants further exploration. Herein, we investigated the potential microbial markers of pancreatic cancer, related research models, the mechanism of action of microbiota in pancreatic cancer, and pancreatic cancer-microbiota-related treatment. Frontiers Media S.A. 2022-03-03 /pmc/articles/PMC8928443/ /pubmed/35309293 http://dx.doi.org/10.3389/fimmu.2022.844401 Text en Copyright © 2022 Chen, Zhang, Dong, Xu and Zhou https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Chen, Zhou
Zhang, Shaofeng
Dong, Shi
Xu, Hao
Zhou, Wence
Association of the Microbiota and Pancreatic Cancer: Opportunities and Limitations
title Association of the Microbiota and Pancreatic Cancer: Opportunities and Limitations
title_full Association of the Microbiota and Pancreatic Cancer: Opportunities and Limitations
title_fullStr Association of the Microbiota and Pancreatic Cancer: Opportunities and Limitations
title_full_unstemmed Association of the Microbiota and Pancreatic Cancer: Opportunities and Limitations
title_short Association of the Microbiota and Pancreatic Cancer: Opportunities and Limitations
title_sort association of the microbiota and pancreatic cancer: opportunities and limitations
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8928443/
https://www.ncbi.nlm.nih.gov/pubmed/35309293
http://dx.doi.org/10.3389/fimmu.2022.844401
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