Re-evaluation of the Fijianolide/Laulimalide Chemotype Suggests an Alternate Mechanism of Action for C-15/C-20 Analogs

[Image: see text] Herein, we report on naturally derived microtubule stabilizers with activity against triple negative breast cancer (TNBC) cell lines, including paclitaxel, fijianolide B/laulimalide (3), fijianolide B di-acetate (4), and two new semisynthetic analogs of 3, which include fijianolide...

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Detalles Bibliográficos
Autores principales: Morris, Joseph D., Takahashi-Ruiz, Leila, Persi, Lauren N., Summers, Jonathan C., McCauley, Erin P., Chan, Peter Y. W., Amberchan, Gabriella, Lizama-Chamu, Itzel, Coppage, David A., Crews, Phillip, Risinger, April L., Johnson, Tyler A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8928504/
https://www.ncbi.nlm.nih.gov/pubmed/35309480
http://dx.doi.org/10.1021/acsomega.1c07146

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