Identification and characterisation of spontaneous mutations causing deafness from a targeted knockout programme

BACKGROUND: Mice carrying targeted mutations are important for investigating gene function and the role of genes in disease, but off-target mutagenic effects associated with the processes of generating targeted alleles, for instance using Crispr, and culturing embryonic stem cells, offer opportuniti...

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Detalles Bibliográficos
Autores principales: Lewis, Morag A., Ingham, Neil J., Chen, Jing, Pearson, Selina, Di Domenico, Francesca, Rekhi, Sohinder, Allen, Rochelle, Drake, Matthew, Willaert, Annelore, Rook, Victoria, Pass, Johanna, Keane, Thomas, Adams, David J., Tucker, Abigail S., White, Jacqueline K., Steel, Karen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8928630/
https://www.ncbi.nlm.nih.gov/pubmed/35296311
http://dx.doi.org/10.1186/s12915-022-01257-8

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