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Tofacitinib Decreases Autophagy of Fibroblast-Like Synoviocytes From Rheumatoid Arthritis Patients

The pathway of Janus tyrosine kinases (JAKs) has a central role in the pathogenesis of Rheumatoid Arthritis (RA) by regulating multiple immune functions and cytokine production. The JAK inhibitor tofacitinib is effective in RA patients not responding to methotrexate or TNF-inhibitors. Since hyperact...

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Detalles Bibliográficos
Autores principales:	Vomero, M., Caliste, M., Barbati, C., Speziali, M., Celia, A. I., Ucci, F., Ciancarella, C., Putro, E., Colasanti, T., Buoncuore, G., Corsiero, E., Bombardieri, M., Spinelli, F. R., Ceccarelli, F., Conti, F., Alessandri, C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8928732/ https://www.ncbi.nlm.nih.gov/pubmed/35308233 http://dx.doi.org/10.3389/fphar.2022.852802

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