Gaussian curvature dilutes the nuclear lamina, favoring nuclear rupture, especially at high strain rate

Nuclear rupture has long been associated with deficits or defects in lamins, with recent results also indicating a role for actomyosin stress, but key physical determinants of rupture remain unclear. Here, lamin-B filaments stably interact with the nuclear membrane at sites of low Gaussian curvature...

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Detalles Bibliográficos
Autores principales: Pfeifer, Charlotte R., Tobin, Michael P., Cho, Sangkyun, Vashisth, Manasvita, Dooling, Lawrence J., Vazquez, Lizeth Lopez, Ricci-De Lucca, Emma G., Simon, Keiann T., Discher, Dennis E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8928808/
https://www.ncbi.nlm.nih.gov/pubmed/35293271
http://dx.doi.org/10.1080/19491034.2022.2045726

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8928808/
https://www.ncbi.nlm.nih.gov/pubmed/35293271
http://dx.doi.org/10.1080/19491034.2022.2045726

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