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Gaussian curvature dilutes the nuclear lamina, favoring nuclear rupture, especially at high strain rate
Nuclear rupture has long been associated with deficits or defects in lamins, with recent results also indicating a role for actomyosin stress, but key physical determinants of rupture remain unclear. Here, lamin-B filaments stably interact with the nuclear membrane at sites of low Gaussian curvature...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8928808/ https://www.ncbi.nlm.nih.gov/pubmed/35293271 http://dx.doi.org/10.1080/19491034.2022.2045726 |