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Evaluation of the inhibitory effect of quercetin on the pharmacokinetics of tucatinib in rats by a novel UPLC–MS/MS assay

CONTEXT: Tucatinib (CYP2C8 substrate) and quercetin (CYP2C8 inhibitor) are two common drugs for the treatment of cancer. However, the effect of quercetin on the metabolism of tucatinib remains unknown. OBJECTIVE: We validated a sensitive method to quantify tucatinib levels in rat plasma based on ult...

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Detalles Bibliográficos
Autores principales:	Zhang, Ying, Liu, Ya-nan, Xie, Saili, Xu, Xuegu, Xu, Ren-ai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8928849/ https://www.ncbi.nlm.nih.gov/pubmed/35289238 http://dx.doi.org/10.1080/13880209.2022.2048862

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